FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000314258> ?p ?o ?g. }

• W2000314258 endingPage "8252" @default.
• W2000314258 startingPage "8248" @default.
• W2000314258 abstract "Experimental analysis of the effects of individual components of complex mammalian systems is frequently impeded by compensatory adjustments that animals make to achieve homeostasis. We here introduce a genetic procedure for eliminating this type of impediment, by using as an example the development and testing of a transgene for genetically clamping the expression of renin, the major homeostatically responding component of the renin-angiotensin system, one of the most important regulators of blood pressure. To obtain a renin transgene whose expression is genetically clamped at a constant level, we have used single-copy chosen-site gene targeting to insert into a liver-specific locus a single copy of a modified mouse renin transgene driven by a liver-specific promoter/enhancer. The resulting transgene expresses renin ectopically at a constant high level in the liver and leads to elevated plasma levels of prorenin and active renin. The transgenic mice display high blood pressure, enhanced thirst, high urine output, proteinuria, and kidney damage. Treatment with the angiotensin II type I receptor antagonist, losartan, reduces the hypertension, albuminuria, and kidney damage, but does not affect expression of the transgene. This genetically clamped renin transgene can be used in models in which hypertension and its complications need to be investigated in a high prorenin/renin environment that is not subject to homeostatic compensations by the animal when other factors are changed." @default.
• W2000314258 created "2016-06-24" @default.
• W2000314258 creator A5024378877 @default.
• W2000314258 creator A5029074504 @default.
• W2000314258 creator A5063192986 @default.
• W2000314258 creator A5064519488 @default.
• W2000314258 creator A5070335657 @default.
• W2000314258 creator A5071362922 @default.
• W2000314258 creator A5081498671 @default.
• W2000314258 creator A5088373188 @default.
• W2000314258 date "2002-05-28" @default.
• W2000314258 modified "2023-10-15" @default.
• W2000314258 title "A genetically clamped renin transgene for the induction of hypertension" @default.
• W2000314258 cites W136497950 @default.
• W2000314258 cites W1518308338 @default.
• W2000314258 cites W163570947 @default.
• W2000314258 cites W1827617621 @default.
• W2000314258 cites W1883375123 @default.
• W2000314258 cites W1965113389 @default.
• W2000314258 cites W1975279384 @default.
• W2000314258 cites W1976924014 @default.
• W2000314258 cites W1985931938 @default.
• W2000314258 cites W1987266465 @default.
• W2000314258 cites W1987622891 @default.
• W2000314258 cites W1991078847 @default.
• W2000314258 cites W1992304926 @default.
• W2000314258 cites W2002886319 @default.
• W2000314258 cites W2003350706 @default.
• W2000314258 cites W2011033656 @default.
• W2000314258 cites W2013821387 @default.
• W2000314258 cites W2016836437 @default.
• W2000314258 cites W2026161101 @default.
• W2000314258 cites W2030350999 @default.
• W2000314258 cites W2032441070 @default.
• W2000314258 cites W2036026169 @default.
• W2000314258 cites W2051124233 @default.
• W2000314258 cites W2054715005 @default.
• W2000314258 cites W2059313610 @default.
• W2000314258 cites W2081213583 @default.
• W2000314258 cites W2085150677 @default.
• W2000314258 cites W2093484801 @default.
• W2000314258 cites W2105912552 @default.
• W2000314258 cites W2115340562 @default.
• W2000314258 cites W2131476379 @default.
• W2000314258 cites W2140796853 @default.
• W2000314258 cites W2145917613 @default.
• W2000314258 cites W2156741803 @default.
• W2000314258 cites W2168800447 @default.
• W2000314258 cites W21751534 @default.
• W2000314258 cites W2412606606 @default.
• W2000314258 cites W2472200701 @default.
• W2000314258 cites W7538965 @default.
• W2000314258 doi "https://doi.org/10.1073/pnas.112222199" @default.
• W2000314258 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/123053" @default.
• W2000314258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12034874" @default.
• W2000314258 hasPublicationYear "2002" @default.
• W2000314258 type Work @default.
• W2000314258 sameAs 2000314258 @default.
• W2000314258 citedByCount "67" @default.
• W2000314258 countsByYear W20003142582012 @default.
• W2000314258 countsByYear W20003142582013 @default.
• W2000314258 countsByYear W20003142582014 @default.
• W2000314258 countsByYear W20003142582015 @default.
• W2000314258 countsByYear W20003142582016 @default.
• W2000314258 countsByYear W20003142582017 @default.
• W2000314258 countsByYear W20003142582018 @default.
• W2000314258 countsByYear W20003142582019 @default.
• W2000314258 countsByYear W20003142582020 @default.
• W2000314258 countsByYear W20003142582021 @default.
• W2000314258 countsByYear W20003142582022 @default.
• W2000314258 countsByYear W20003142582023 @default.
• W2000314258 crossrefType "journal-article" @default.
• W2000314258 hasAuthorship W2000314258A5024378877 @default.
• W2000314258 hasAuthorship W2000314258A5029074504 @default.
• W2000314258 hasAuthorship W2000314258A5063192986 @default.
• W2000314258 hasAuthorship W2000314258A5064519488 @default.
• W2000314258 hasAuthorship W2000314258A5070335657 @default.
• W2000314258 hasAuthorship W2000314258A5071362922 @default.
• W2000314258 hasAuthorship W2000314258A5081498671 @default.
• W2000314258 hasAuthorship W2000314258A5088373188 @default.
• W2000314258 hasBestOaLocation W20003142581 @default.
• W2000314258 hasConcept C102230213 @default.
• W2000314258 hasConcept C104317684 @default.
• W2000314258 hasConcept C126322002 @default.
• W2000314258 hasConcept C134018914 @default.
• W2000314258 hasConcept C141035611 @default.
• W2000314258 hasConcept C198710026 @default.
• W2000314258 hasConcept C2780091579 @default.
• W2000314258 hasConcept C2780288358 @default.
• W2000314258 hasConcept C2908929049 @default.
• W2000314258 hasConcept C54355233 @default.
• W2000314258 hasConcept C71924100 @default.
• W2000314258 hasConcept C84393581 @default.
• W2000314258 hasConcept C86803240 @default.
• W2000314258 hasConceptScore W2000314258C102230213 @default.
• W2000314258 hasConceptScore W2000314258C104317684 @default.
• W2000314258 hasConceptScore W2000314258C126322002 @default.
• W2000314258 hasConceptScore W2000314258C134018914 @default.

• next