Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000314587> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2000314587 endingPage "629" @default.
- W2000314587 startingPage "623" @default.
- W2000314587 abstract "Altered cytokine metabolism has been implicated in the pathogenesis of alcoholic liver disease. Recently, autoantibodies to cytokines have been proposed to act as modifiers of cytokine functions. In this study plasma levels of anti‐interleukin‐1α (IL‐1α autoantibodies and anti‐IL‐6 autoantibodies were determined by RIAs in 96 patients with alcoholic cirrhosis and in 16 healthy individuals. After 19 months (median) the prognostic significance of the cytokine autoantibodies was investigated using univariate analysis (Log‐rank test) and multivariate regression analysis (Cox model). The seroprevalences of anti‐IL‐1α autoantibodies and anti‐IL‐6 autoantibodies (42 and 18%, respectively) in the patients were not different from healthy individuals and did not relate to severity of liver disease. The presence of anti‐IL‐1α autoantibodies was of no prognostic significance. Independent of severity of liver disease, patients with anti‐IL‐6 autoantibodies in plasma had a higher risk of acquiring infections and higher risk of death ( P < 0.02) compared to patients without anti‐IL‐6 autoantibodies. The authors concluded that anti‐IL‐6 autoantibodies are associated with increased mortality when present in the plasma of patients with alcoholic cirrhosis, which is probably secondary to recurrent infections, but not to underlying severity of liver disease." @default.
- W2000314587 created "2016-06-24" @default.
- W2000314587 creator A5007619326 @default.
- W2000314587 creator A5008555274 @default.
- W2000314587 creator A5021941649 @default.
- W2000314587 creator A5033919001 @default.
- W2000314587 creator A5044491476 @default.
- W2000314587 creator A5053483999 @default.
- W2000314587 creator A5061950161 @default.
- W2000314587 creator A5088476938 @default.
- W2000314587 date "1996-11-01" @default.
- W2000314587 modified "2023-10-02" @default.
- W2000314587 title "Anti‐Interleukin‐6 Autoantibodies in Plasma are Associated with an Increased Frequency of Infections and Increased Mortality of Patients with Alcoholic Cirrhosis" @default.
- W2000314587 doi "https://doi.org/10.1046/j.1365-3083.1996.d01-344.x" @default.
- W2000314587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8972745" @default.
- W2000314587 hasPublicationYear "1996" @default.
- W2000314587 type Work @default.
- W2000314587 sameAs 2000314587 @default.
- W2000314587 citedByCount "29" @default.
- W2000314587 countsByYear W20003145872012 @default.
- W2000314587 countsByYear W20003145872014 @default.
- W2000314587 countsByYear W20003145872015 @default.
- W2000314587 countsByYear W20003145872016 @default.
- W2000314587 countsByYear W20003145872017 @default.
- W2000314587 countsByYear W20003145872019 @default.
- W2000314587 countsByYear W20003145872020 @default.
- W2000314587 countsByYear W20003145872022 @default.
- W2000314587 countsByYear W20003145872023 @default.
- W2000314587 crossrefType "journal-article" @default.
- W2000314587 hasAuthorship W2000314587A5007619326 @default.
- W2000314587 hasAuthorship W2000314587A5008555274 @default.
- W2000314587 hasAuthorship W2000314587A5021941649 @default.
- W2000314587 hasAuthorship W2000314587A5033919001 @default.
- W2000314587 hasAuthorship W2000314587A5044491476 @default.
- W2000314587 hasAuthorship W2000314587A5053483999 @default.
- W2000314587 hasAuthorship W2000314587A5061950161 @default.
- W2000314587 hasAuthorship W2000314587A5088476938 @default.
- W2000314587 hasConcept C126322002 @default.
- W2000314587 hasConcept C159654299 @default.
- W2000314587 hasConcept C163764329 @default.
- W2000314587 hasConcept C203014093 @default.
- W2000314587 hasConcept C2777075537 @default.
- W2000314587 hasConcept C2777214474 @default.
- W2000314587 hasConcept C2777575235 @default.
- W2000314587 hasConcept C2778690821 @default.
- W2000314587 hasConcept C2779134260 @default.
- W2000314587 hasConcept C2780942790 @default.
- W2000314587 hasConcept C71924100 @default.
- W2000314587 hasConcept C90924648 @default.
- W2000314587 hasConceptScore W2000314587C126322002 @default.
- W2000314587 hasConceptScore W2000314587C159654299 @default.
- W2000314587 hasConceptScore W2000314587C163764329 @default.
- W2000314587 hasConceptScore W2000314587C203014093 @default.
- W2000314587 hasConceptScore W2000314587C2777075537 @default.
- W2000314587 hasConceptScore W2000314587C2777214474 @default.
- W2000314587 hasConceptScore W2000314587C2777575235 @default.
- W2000314587 hasConceptScore W2000314587C2778690821 @default.
- W2000314587 hasConceptScore W2000314587C2779134260 @default.
- W2000314587 hasConceptScore W2000314587C2780942790 @default.
- W2000314587 hasConceptScore W2000314587C71924100 @default.
- W2000314587 hasConceptScore W2000314587C90924648 @default.
- W2000314587 hasIssue "6" @default.
- W2000314587 hasLocation W20003145871 @default.
- W2000314587 hasLocation W20003145872 @default.
- W2000314587 hasOpenAccess W2000314587 @default.
- W2000314587 hasPrimaryLocation W20003145871 @default.
- W2000314587 hasRelatedWork W2037468041 @default.
- W2000314587 hasRelatedWork W2153568700 @default.
- W2000314587 hasRelatedWork W2161019027 @default.
- W2000314587 hasRelatedWork W2317914672 @default.
- W2000314587 hasRelatedWork W2357475556 @default.
- W2000314587 hasRelatedWork W2419247513 @default.
- W2000314587 hasRelatedWork W2956245133 @default.
- W2000314587 hasRelatedWork W3032623092 @default.
- W2000314587 hasRelatedWork W3125479117 @default.
- W2000314587 hasRelatedWork W4375863185 @default.
- W2000314587 hasVolume "44" @default.
- W2000314587 isParatext "false" @default.
- W2000314587 isRetracted "false" @default.
- W2000314587 magId "2000314587" @default.
- W2000314587 workType "article" @default.