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- W2000314593 abstract "Marked hypertriglyceridemia and hypercholesterolemia accompanied by angina and a left cerebral thrombosis occurred in a long-term hemodialysis patient following 5 1/2 weeks of oral treatment with oxymetholone, 100 mg/day, a synthetic androgen. After androgen therapy was discontinued, over a three-month period, plasma lipid values progressively decreased below pretreatment values, and clinical symptoms disappeared. During rechallenge with oxymetholone, serum lipid values increased substantially, and the lipoprotein pattern changed from a type IV to a type V. Detailed lipid studies showed subnormal postheparin lipolytic activity and a fast-migrating pre-β-lipoprotein in the very-low-density lipoproteins (VLDL) fraction. Because of the data linking lipid abnormalities to atherosclerosis and the acceleration of atherosclerosis in long-term hemodialysis patients, great caution should be exercised in administering androgenic steroids to these patients. (<i>JAMA</i>236:469-472, 1976)" @default.
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- W2000314593 date "1976-08-02" @default.
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- W2000314593 title "Hyperlipidemia Due to Oxymetholone Therapy" @default.
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- W2000314593 doi "https://doi.org/10.1001/jama.1976.03270050025023" @default.
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