Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000315416> ?p ?o ?g. }
- W2000315416 endingPage "438" @default.
- W2000315416 startingPage "431" @default.
- W2000315416 abstract "A wide range of pollutants in the aquatic environment have the capacity to induce toxic effects expressed as cellular oxidative stress. In the current study, the potential of an in vitro toxicity testing system was therefore investigated using rainbow trout (Oncorhynchus mykiss) hepatocytes to assess different endpoints of oxidative stress. The pro-oxidants CuSO(4) and paraquat were used as models for comparison to a complex environmental sample. Results following 6, 24, 48 and 96h exposure to different concentrations of these substances show cellular effects on intracellular ROS formation, glutathione levels and redox status, expression of the antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, gamma-glutamyl-cysteine synthetase (GCS) and thioredoxin, as well as cytotoxicity parameters. The most consistent effects (maximum values within brackets), observed in dose and time parameters for both model compounds and environmental sample, were the depletion of total glutathione (9.4% of control), induced levels of oxidized glutathione (695% of control), and gene expression regulation depicted relative to the control gene beta-actin of GCS mRNA (239% of control) and catalase (29% of control). In conclusion, the responses on several antioxidant defence system parameters demonstrated the validity of the in vitro toxicity testing system. Not only could multiple effects be detected at sub-lethal exposure concentrations, but these effects also gave valuable insight to the toxic mechanisms at the molecular level." @default.
- W2000315416 created "2016-06-24" @default.
- W2000315416 creator A5000511117 @default.
- W2000315416 creator A5028625152 @default.
- W2000315416 creator A5058432721 @default.
- W2000315416 creator A5078383878 @default.
- W2000315416 creator A5090748501 @default.
- W2000315416 date "2010-05-01" @default.
- W2000315416 modified "2023-10-16" @default.
- W2000315416 title "Oxidative stress responses in rainbow trout (Oncorhynchus mykiss) hepatocytes exposed to pro-oxidants and a complex environmental sample" @default.
- W2000315416 cites W1528606854 @default.
- W2000315416 cites W1541649582 @default.
- W2000315416 cites W1964488482 @default.
- W2000315416 cites W1971759071 @default.
- W2000315416 cites W1976911231 @default.
- W2000315416 cites W1987307644 @default.
- W2000315416 cites W1991443169 @default.
- W2000315416 cites W1993668342 @default.
- W2000315416 cites W1995572578 @default.
- W2000315416 cites W1998938457 @default.
- W2000315416 cites W2002293394 @default.
- W2000315416 cites W2002792636 @default.
- W2000315416 cites W2005211634 @default.
- W2000315416 cites W2008167774 @default.
- W2000315416 cites W2014235257 @default.
- W2000315416 cites W2014541052 @default.
- W2000315416 cites W2016860528 @default.
- W2000315416 cites W2018871465 @default.
- W2000315416 cites W2020469902 @default.
- W2000315416 cites W2021782116 @default.
- W2000315416 cites W2029007583 @default.
- W2000315416 cites W2031832329 @default.
- W2000315416 cites W2036982293 @default.
- W2000315416 cites W2047758994 @default.
- W2000315416 cites W2049192526 @default.
- W2000315416 cites W2049933635 @default.
- W2000315416 cites W2060696438 @default.
- W2000315416 cites W2061244362 @default.
- W2000315416 cites W2061566733 @default.
- W2000315416 cites W2074361846 @default.
- W2000315416 cites W2075480615 @default.
- W2000315416 cites W2076134807 @default.
- W2000315416 cites W2076940944 @default.
- W2000315416 cites W2085527914 @default.
- W2000315416 cites W2085601435 @default.
- W2000315416 cites W2087419479 @default.
- W2000315416 cites W2091418091 @default.
- W2000315416 cites W2092279892 @default.
- W2000315416 cites W2093278911 @default.
- W2000315416 cites W2104901573 @default.
- W2000315416 cites W2107001713 @default.
- W2000315416 cites W2149242340 @default.
- W2000315416 cites W2166855152 @default.
- W2000315416 cites W2170800444 @default.
- W2000315416 cites W2409995817 @default.
- W2000315416 cites W29316891 @default.
- W2000315416 cites W4245957869 @default.
- W2000315416 doi "https://doi.org/10.1016/j.cbpc.2010.01.008" @default.
- W2000315416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20116453" @default.
- W2000315416 hasPublicationYear "2010" @default.
- W2000315416 type Work @default.
- W2000315416 sameAs 2000315416 @default.
- W2000315416 citedByCount "10" @default.
- W2000315416 countsByYear W20003154162012 @default.
- W2000315416 countsByYear W20003154162013 @default.
- W2000315416 countsByYear W20003154162014 @default.
- W2000315416 countsByYear W20003154162016 @default.
- W2000315416 countsByYear W20003154162018 @default.
- W2000315416 countsByYear W20003154162021 @default.
- W2000315416 crossrefType "journal-article" @default.
- W2000315416 hasAuthorship W2000315416A5000511117 @default.
- W2000315416 hasAuthorship W2000315416A5028625152 @default.
- W2000315416 hasAuthorship W2000315416A5058432721 @default.
- W2000315416 hasAuthorship W2000315416A5078383878 @default.
- W2000315416 hasAuthorship W2000315416A5090748501 @default.
- W2000315416 hasConcept C165069038 @default.
- W2000315416 hasConcept C178790620 @default.
- W2000315416 hasConcept C181199279 @default.
- W2000315416 hasConcept C185592680 @default.
- W2000315416 hasConcept C2775838275 @default.
- W2000315416 hasConcept C2776151105 @default.
- W2000315416 hasConcept C2776527163 @default.
- W2000315416 hasConcept C2777737464 @default.
- W2000315416 hasConcept C2778004101 @default.
- W2000315416 hasConcept C2778760513 @default.
- W2000315416 hasConcept C2778979269 @default.
- W2000315416 hasConcept C2909208804 @default.
- W2000315416 hasConcept C29730261 @default.
- W2000315416 hasConcept C2994167347 @default.
- W2000315416 hasConcept C3623737 @default.
- W2000315416 hasConcept C48349386 @default.
- W2000315416 hasConcept C505870484 @default.
- W2000315416 hasConcept C538909803 @default.
- W2000315416 hasConcept C55493867 @default.
- W2000315416 hasConcept C86803240 @default.
- W2000315416 hasConceptScore W2000315416C165069038 @default.
- W2000315416 hasConceptScore W2000315416C178790620 @default.
- W2000315416 hasConceptScore W2000315416C181199279 @default.