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• W2000319050 abstract "Abstract Aim: To better predict treatment responses for managing bulky cervical carcinoma with neoadjuvant chemotherapy (NAC). Methods: The expression of p‐STAT3 was analyzed by immunohistochemistry using paraffin‐embedded pretreatment cervical biopsy tissues. The study included 29 patients with bulky IB to IIA cervical squamous cell carcinoma treated with NAC. Results: Twenty (69.0%) of 29 patients were scored as p‐STAT3‐positive. Pathological response to chemotherapy (complete response or residual tumor with less than 3 mm stromal invasion) was observed in eight patients (27.6%). The p‐STAT3‐positive patients had a longer disease‐free survival compared to p‐STAT3‐negative patients ( P = 0.03), though they had more frequent clinical nodal involvement ( P = 0.046). Conclusion: Pretreatment assessment of p‐STAT3 expression may provide additional information for the identification of patients with cervical cancer who have a favorable prognosis." @default.
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• W2000319050 date "2010-03-25" @default.
• W2000319050 modified "2023-10-18" @default.
• W2000319050 title "Prognostic significance of p-STAT3 in patients with bulky cervical carcinoma undergoing neoadjuvant chemotherapy" @default.
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• W2000319050 doi "https://doi.org/10.1111/j.1447-0756.2009.01131.x" @default.
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