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- W2000320452 abstract "Pardaxin is an excitatory polypeptide toxin from the Moses sole fish which triggers neurotransmitter release from a variety of nerve terminals. We have used several pharmacologial manipulations for studying the mechanisms of pardaxin-induced neurotransmitter release using catecholaminergic neurons.At noncytotoxic concentrations (<10−5M) pardaxin stimulated exocytosis as assessed by the concomitant release of catecholamines, ATP and dopamine-ß-hydroxylase in the presence or absence of extracellular calcium. The role of intracellular calcium in pardaxin action was investigated by using the fluorescent calcium indicator Fura-2 and 45Ca fluxes. In the presence, but not in the absence, of extracellular calcium, pardaxin produced a steady, concentration-dependent rise in intracellular calcium. The pardaxin-induced calcium influx is partially inhibited (15%) by nifedipine, occurred in PC12 cells in which L-calcium channels were down-regulated by Bay K-8644, indicating a major role of pardaxin pores in the calcium influx. The fact that pardaxin also stimulated catecholamines secretion without a rise in intracellular calcium suggest that the toxin in addition to being a pore-forming compound might affect exocytosis by calcium independent pathway(s).A pharmacological working model is proposed for studying the cellular signals induced by pardaxin to trigger neurotransmitter exocytosis. We suggest pardaxin as a pharmacological ionophore tool to modulate and investigate neuronal calcium homeostasis and synaptic transmission." @default.
- W2000320452 created "2016-06-24" @default.
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- W2000320452 date "1994-01-01" @default.
- W2000320452 modified "2023-09-27" @default.
- W2000320452 title "Challenging Catecholamine Exocytosis with Pardaxin, an Excitatory Ionophore Fish Toxin" @default.
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- W2000320452 doi "https://doi.org/10.3109/15569549409006480" @default.
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