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• W2000321745 abstract "The phagocyte NADPH oxidase is a multicomponent enzyme complex mediating microbial killing. We find that NADPH oxidase p47phox-deficient (p47phox−/−) chronic granulomatous disease (CGD) mice develop lymph node hyperplasia even without obvious infection, where increased number of T and B lymphocytes is associated with increased percent of naïve cells and a lower T : B cell ratio than wild type. Paradoxically, despite lymphoid hyperplasia in vivo, when lymphocytes are placed in culture, p47phox−/− CD8+ lymphocytes progress more rapidly to apoptosis than wild type. This is associated in cultured p47phox−/− CD8+ lymphocytes with the induction of proapoptotic Bim and Puma expression, increased mitochondrial outer membrane permeabilization and depressed Bcl-2 expression. Addition of IL-7 to the culture partially corrects Bcl-2 levels in cultured p47phox−/− CD8+ lymphocytes and improves the survival. Adding glucose oxidase to the culture to generate hydrogen peroxide along with IL-7 further improves p47phox−/− CD8+ lymphocyte survival, but only to 30% of wild type. We conclude that p47phox−/− CD8+ lymphocytes have an intrinsic survival defect likely in part related to the oxidase deficiency, but in vivo in lymph nodes of CGD mice, there are microenvironmental factors yet to be delineated that suppress the progression of apoptosis and allow the accumulation of lymphocytes leading to lymphoid hyperplasia." @default.
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• W2000321745 date "2008-09-19" @default.
• W2000321745 modified "2023-10-17" @default.
• W2000321745 title "p47phox-deficient immune microenvironment signals dysregulate naive T-cell apoptosis" @default.
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• W2000321745 doi "https://doi.org/10.1038/cdd.2008.129" @default.
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