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• W2000321746 abstract "The main purpose of free T4 and free T3 assays is to distinguish reliably between thyrotoxicosis, hypothyroidism, and the euthyroid state, an objective that cannot be attained with assays of total T4 and T3 because of hereditary and acquired variations in the concentrations of binding proteins. Effective correction for changes in the serum concentration of TBG can be achieved with numerous types of free hormone estimate, but other changes in binding are not well accommodated. Despite remarkable methodologic ingenuity, no current method reflects the free T4 concentration in undiluted serum under in vivo conditions. Equilibrium dialysis, widely considered the reference method for free T4 measurement, is also subject to error, either preanalytic, owing to generation of NEFA in the sample leading to an overestimate of free T4, or analytic with underestimation of the effect of competitors to increase free T4. Current approaches to free T4 measurement are vulnerable to several method-dependent artifacts: abnormal albumin binding of T4 or of the assay tracer, the inhibition of T4 binding to TBG by medications, and the effects of critical illness, especially in heparin-treated patients, pregnancy, and the abnormalities in sick premature infants. Because of systematic variation between methods (i.e., whether a technique is albumin dependent or prone to incubation or dilution artifacts), it is essential to consider methodologic details in evaluating free T4 estimates in these situations and whenever estimates of free T4 are clinically discordant. False-positive abnormalities are more frequent than false-negative results. When free T4 results are correlated with the serum TSH concentration with attention to the assumptions that define this relationship, the majority of false-positive results can be readily identified. If a free T4 anomaly remains unexplained on repeat sampling, it is appropriate to use an alternative free T4 method that depends on a different assay principle and to correlate the result with an authentic total T4 measurement." @default.
• W2000321746 created "2016-06-24" @default.
• W2000321746 creator A5027348796 @default.
• W2000321746 date "2001-06-01" @default.
• W2000321746 modified "2023-10-18" @default.
• W2000321746 title "FREE THYROID HORMONE MEASUREMENT" @default.
• W2000321746 cites W1837111152 @default.
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• W2000321746 cites W1942315509 @default.
• W2000321746 cites W1952077050 @default.
• W2000321746 cites W1963772854 @default.
• W2000321746 cites W1964693382 @default.
• W2000321746 cites W1965743926 @default.
• W2000321746 cites W1969480060 @default.
• W2000321746 cites W1971970302 @default.
• W2000321746 cites W1979562310 @default.
• W2000321746 cites W1991240873 @default.
• W2000321746 cites W1992657280 @default.
• W2000321746 cites W1995993817 @default.
• W2000321746 cites W2000761970 @default.
• W2000321746 cites W2005974273 @default.
• W2000321746 cites W2006671286 @default.
• W2000321746 cites W2008216634 @default.
• W2000321746 cites W2009092385 @default.
• W2000321746 cites W2013504654 @default.
• W2000321746 cites W2014412718 @default.
• W2000321746 cites W2015768034 @default.
• W2000321746 cites W201584597 @default.
• W2000321746 cites W2017768507 @default.
• W2000321746 cites W2023583183 @default.
• W2000321746 cites W2029520132 @default.
• W2000321746 cites W2031541421 @default.
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• W2000321746 cites W2042157916 @default.
• W2000321746 cites W2044555720 @default.
• W2000321746 cites W2046736515 @default.
• W2000321746 cites W2058620063 @default.
• W2000321746 cites W2060645482 @default.
• W2000321746 cites W2064224355 @default.
• W2000321746 cites W2067300201 @default.
• W2000321746 cites W2070360705 @default.
• W2000321746 cites W2070967589 @default.
• W2000321746 cites W2075311180 @default.
• W2000321746 cites W2077493254 @default.
• W2000321746 cites W2077508020 @default.
• W2000321746 cites W2078292462 @default.
• W2000321746 cites W2081808749 @default.
• W2000321746 cites W2085003167 @default.
• W2000321746 cites W2093125204 @default.
• W2000321746 cites W2100762343 @default.
• W2000321746 cites W2105902453 @default.
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• W2000321746 cites W2122371240 @default.
• W2000321746 cites W2128828392 @default.
• W2000321746 cites W2131125608 @default.
• W2000321746 cites W2137976920 @default.
• W2000321746 cites W2149547682 @default.
• W2000321746 cites W2163480387 @default.
• W2000321746 cites W2223292536 @default.
• W2000321746 cites W2324164337 @default.
• W2000321746 cites W2334574028 @default.
• W2000321746 cites W2334882251 @default.
• W2000321746 cites W2339926369 @default.
• W2000321746 cites W2410006890 @default.
• W2000321746 cites W3000090277 @default.
• W2000321746 cites W3022017015 @default.
• W2000321746 cites W4231404551 @default.
• W2000321746 cites W4231839510 @default.
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• W2000321746 doi "https://doi.org/10.1016/s0889-8529(05)70187-0" @default.
• W2000321746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11444163" @default.
• W2000321746 hasPublicationYear "2001" @default.
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