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• W2000322006 abstract "Gas embolism results from a negative pressure gradient between veins exposed to air and the central venous pressure.1Albin M.S. Carroll R.G. Maroon J.C. Clinical considerations concerning detection of venous air embolism.Neurosurgery. 1978; 3: 380-384Crossref PubMed Scopus (95) Google Scholar The incidence varies according to the procedure, the position, and the detection method used. Venous air embolism (VAE) in cardiac surgery has been previously observed during central venous cannulation and while opening the heart chambers during cardiopulmonary bypass.2Propst J.W. Siegel L.C. Schnittger I. Foppiano L. Goodman S.B. Brock-Utne J.G. Segmental wall motion abnormalities in patients undergoing total hip replacement correlations with intraoperative events.Anesth Analg. 1993; 77: 743-749Crossref PubMed Google Scholar We now describe, for the first time, the detection of VAE by transesophageal echocardiography during sternotomy in children undergoing corrective heart surgery. In addition, we show that sternotomy with scissors significantly reduces the risk of embolization compared with using a saw. Twenty children scheduled for corrective heart surgery were enrolled. Patients with a previous sternotomy were excluded. Patients were randomly assigned to the saw or scissors group. Ten children who underwent sternotomy with a saw had a ventricular septal defect (n = 2), total anomalous pulmonary venous return (n = 1), tetralogy of Fallot (n = 1), truncus arteriosus (n = 1), mitral stenosis (n = 1), or double-outlet right ventricle (n = 1). The other 10 children who underwent sternotomy with scissors had an atrial septal defect (n = 2), ventricular septal defect (n = 2), tetralogy of Fallot (n = 2), total anomalous pulmonary venous return (n = 1), hypoplastic left heart syndrome (n = 1), transposition of the great arteries (n = 1), and cor triatriatum (n = 1). Monitoring included electrocardiogram, pulse oximetry, end-tidal carbon dioxide, invasive arterial blood pressure, and central venous pressure. During sternotomy, patients were disconnected from the ventilator, and no fluids or medications were infused. A 4-chamber view of the heart was obtained by a 5.0-MHz multiplane transesophageal echocardiography transducer (SONOS 5500; Hewlett-Packard, Andover, Mass). The transducer was positioned so that the right atrium was in the center of the screen. Data were recorded by a videotape. The number of VAEs was assessed qualitatively, per patient, by 3 pediatric cardiologists with clinical experience in intraoperative echocardiography. They were blinded to the method of sternotomy. The VAEs detected for each patient were defined on a scale of 0 to 3, where 0 indicated no targets, 1 indicated occasional targets, 2 indicated many targets, and 3 indicated targets filling the entire atrium.2Propst J.W. Siegel L.C. Schnittger I. Foppiano L. Goodman S.B. Brock-Utne J.G. Segmental wall motion abnormalities in patients undergoing total hip replacement correlations with intraoperative events.Anesth Analg. 1993; 77: 743-749Crossref PubMed Google Scholar The results of the 3 echocardiographic evaluations were averaged per patient, and a comparison between groups was performed by using the Mann-Whitney rank sum test. VAEs were detected in 14 (70%) patients. Most emboli were small (<2 mm) and appeared similar to the microbubbles produced by agitating saline with a small amount of air (Figure 1). The incidence was significantly higher (P < .002) when sternotomy was performed with a saw compared with scissors (Table 1). The peak number of emboli appeared approximately 5 seconds after sternotomy and returned to baseline at the end of the procedure. Six patients also had larger (>5 mm) emboli that appeared to be solid material. Passage of emboli to the left cardiac chambers was detected in 5 patients (25%) with a known right-to-left shunt and in whom sternotomy was performed with a saw. No significant hemodynamic changes or changes in end-tidal carbon dioxide or arterial saturation between preprocedure and postprocedure values were detected.TABLE 1Comparison of intracardiac emboli between children undergoing sternotomy with a saw versus scissorsVariableSaw (n = 10)Scissors (n = 10)Intracardiac embol vs. scale (mean ± SD)1.90 ± 0.83*P < .002; Mann-Whitney sum rank test.0.41 ± 0.46Median2.00.33Lower 95% CI1.30.02Upper 95% CI2.490.80CI, Confidence interval.* P < .002; Mann-Whitney sum rank test. Open table in a new tab CI, Confidence interval. Children are less prone to VAE than adults, but they are more susceptible to the side effects, especially when a right-to-left shunt exists.3Venous air embolism. In: Bissonnette B, Dalens B, editors. Pediatric anesthesia: principles and practice. New York: McGraw-Hill; 2002. p. 1130-1Google Scholar The incidence of VAE increases when a vein that cannot collapse is opened,4Palmon S.C. Moore L.E. Lundberg J. Toung T. Venous air embolism a review.J Clin Anesth. 1997; 9: 251-257Abstract Full Text PDF PubMed Scopus (181) Google Scholar such as the cranial diploic veins. Other risk factors for VAE are large airway pressure variations, which were shown to decrease venous pressure to subatmospheric levels.5Muth C.M. Shank E.S. Gas embolism.N Engl J Med. 2000; 342: 476-482Crossref PubMed Scopus (706) Google Scholar The same risk factors were present in our study population: opening of the sternum veins bears some similarity to the opening of the cranial vault veins, and disconnecting the endotracheal tube just before sternotomy decreases airway pressure. Furthermore, 5 (25%) of our patients had a preexisting right-to-left shunt, again increasing the likelihood of clinically significant VAE. The fact that embolus incidence was higher with the saw compared with the scissors is not straightforward. It would seem that the saw would result in less compression of the bone marrow, thus being less traumatic. One may hypothesize that the vibration caused by the saw action induces microbubble formation such as in agitated saline. This hypothesis was tested by pressing the saw against the closed chest wall, thus testing the effects of the vibrations alone. No emboli were detected. Another explanation might be that the vibrations cause increased small amounts of air entrainment in the open vessels. This hypothesis has not been tested. In summary, our results suggest that VAE during sternotomy is a frequent occurrence and that the number of emboli is related to the method of sternotomy." @default.
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• W2000322006 title "Venous embolization during sternotomy in children undergoing corrective heart surgery" @default.
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