FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000322240> ?p ?o ?g. }

• W2000322240 endingPage "117" @default.
• W2000322240 startingPage "109" @default.
• W2000322240 abstract "Effects of endothelin-1 on the contraction and cytosolic Ca2+ concentrations ([Ca2+]i) of the mouse right ventricle were investigated. Endothelin-1 (1–300 nM) elicited a negative inotropic effect in a concentration-dependent manner. The endothelin-1-induced negative inotropy was antagonized by a selective endothelin ETA receptor antagonist, BQ-123 (cyclo [Asp-Pro-Val-Leu-Trp-]; 3, 10 μM). Endothelin-1 reduced the peak amplitudes of both the [Ca2+]i transient and contraction without changing inward Ca2+ current. The relationship between peak amplitude of [Ca2+]i and peak force generated by changing the extracellular Ca2+ concentration ([Ca2+]o) was not affected by endothelin-1. In addition, the trajectory of the [Ca2+]i-contraction phase plane diagram obtained at 2 mM [Ca2+]o in the absence of endothelin-1 was superimposable on that obtained at 4 mM [Ca2+]o in the presence of endothelin-1 (300 nM). Endothelin-1 (300 nM) translocated protein kinase C from cytosol to membrane, suggesting activation of protein kinase C. Further, a selective protein kinase C inhibitor, bisindolylmaleimide I (10 μM), inhibited the endothelin-1-induced negative inotropy. These results suggest that endothelin-1 elicits negative inotropy by reducing the amplitude of the [Ca2+]i transient without changing inward Ca2+ current through the activation of the endothelin ETA receptor followed by protein kinase C activation in the mouse right ventricle." @default.
• W2000322240 created "2016-06-24" @default.
• W2000322240 creator A5006676797 @default.
• W2000322240 creator A5010499089 @default.
• W2000322240 creator A5012320784 @default.
• W2000322240 creator A5050233578 @default.
• W2000322240 creator A5088628108 @default.
• W2000322240 date "2000-05-01" @default.
• W2000322240 modified "2023-10-15" @default.
• W2000322240 title "Negative inotropic effect of endothelin-1 in the mouse right ventricle" @default.
• W2000322240 cites W1530373502 @default.
• W2000322240 cites W1548858272 @default.
• W2000322240 cites W1755902553 @default.
• W2000322240 cites W18385981 @default.
• W2000322240 cites W1960936481 @default.
• W2000322240 cites W1967688761 @default.
• W2000322240 cites W1971882283 @default.
• W2000322240 cites W1975193741 @default.
• W2000322240 cites W1979131372 @default.
• W2000322240 cites W1988345896 @default.
• W2000322240 cites W1995479770 @default.
• W2000322240 cites W2007147992 @default.
• W2000322240 cites W2007801010 @default.
• W2000322240 cites W2012139184 @default.
• W2000322240 cites W2046102701 @default.
• W2000322240 cites W2048660168 @default.
• W2000322240 cites W2059224786 @default.
• W2000322240 cites W2061895140 @default.
• W2000322240 cites W2067636590 @default.
• W2000322240 cites W2087750804 @default.
• W2000322240 cites W2093006711 @default.
• W2000322240 cites W2094074899 @default.
• W2000322240 cites W2135672526 @default.
• W2000322240 cites W2159438452 @default.
• W2000322240 cites W2160962428 @default.
• W2000322240 cites W2167923245 @default.
• W2000322240 doi "https://doi.org/10.1016/s0014-2999(00)00218-1" @default.
• W2000322240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10822063" @default.
• W2000322240 hasPublicationYear "2000" @default.
• W2000322240 type Work @default.
• W2000322240 sameAs 2000322240 @default.
• W2000322240 citedByCount "18" @default.
• W2000322240 countsByYear W20003222402012 @default.
• W2000322240 countsByYear W20003222402018 @default.
• W2000322240 crossrefType "journal-article" @default.
• W2000322240 hasAuthorship W2000322240A5006676797 @default.
• W2000322240 hasAuthorship W2000322240A5010499089 @default.
• W2000322240 hasAuthorship W2000322240A5012320784 @default.
• W2000322240 hasAuthorship W2000322240A5050233578 @default.
• W2000322240 hasAuthorship W2000322240A5088628108 @default.
• W2000322240 hasConcept C12554922 @default.
• W2000322240 hasConcept C126322002 @default.
• W2000322240 hasConcept C134018914 @default.
• W2000322240 hasConcept C144980905 @default.
• W2000322240 hasConcept C149601957 @default.
• W2000322240 hasConcept C155710745 @default.
• W2000322240 hasConcept C163415756 @default.
• W2000322240 hasConcept C170493617 @default.
• W2000322240 hasConcept C184235292 @default.
• W2000322240 hasConcept C185592680 @default.
• W2000322240 hasConcept C195794163 @default.
• W2000322240 hasConcept C2778921608 @default.
• W2000322240 hasConcept C2909649922 @default.
• W2000322240 hasConcept C55493867 @default.
• W2000322240 hasConcept C71924100 @default.
• W2000322240 hasConcept C86803240 @default.
• W2000322240 hasConceptScore W2000322240C12554922 @default.
• W2000322240 hasConceptScore W2000322240C126322002 @default.
• W2000322240 hasConceptScore W2000322240C134018914 @default.
• W2000322240 hasConceptScore W2000322240C144980905 @default.
• W2000322240 hasConceptScore W2000322240C149601957 @default.
• W2000322240 hasConceptScore W2000322240C155710745 @default.
• W2000322240 hasConceptScore W2000322240C163415756 @default.
• W2000322240 hasConceptScore W2000322240C170493617 @default.
• W2000322240 hasConceptScore W2000322240C184235292 @default.
• W2000322240 hasConceptScore W2000322240C185592680 @default.
• W2000322240 hasConceptScore W2000322240C195794163 @default.
• W2000322240 hasConceptScore W2000322240C2778921608 @default.
• W2000322240 hasConceptScore W2000322240C2909649922 @default.
• W2000322240 hasConceptScore W2000322240C55493867 @default.
• W2000322240 hasConceptScore W2000322240C71924100 @default.
• W2000322240 hasConceptScore W2000322240C86803240 @default.
• W2000322240 hasIssue "2-3" @default.
• W2000322240 hasLocation W20003222401 @default.
• W2000322240 hasLocation W20003222402 @default.
• W2000322240 hasOpenAccess W2000322240 @default.
• W2000322240 hasPrimaryLocation W20003222401 @default.
• W2000322240 hasRelatedWork W1983371938 @default.
• W2000322240 hasRelatedWork W1997169304 @default.
• W2000322240 hasRelatedWork W1998988813 @default.
• W2000322240 hasRelatedWork W2010509942 @default.
• W2000322240 hasRelatedWork W2022076253 @default.
• W2000322240 hasRelatedWork W2032437128 @default.
• W2000322240 hasRelatedWork W2038012085 @default.
• W2000322240 hasRelatedWork W2141307244 @default.
• W2000322240 hasRelatedWork W2160355439 @default.
• W2000322240 hasRelatedWork W2413793517 @default.
• W2000322240 hasVolume "396" @default.

• next