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- W2000322433 endingPage "1074" @default.
- W2000322433 startingPage "1055" @default.
- W2000322433 abstract "Here we review viral and cellular requirements for entry and intracellular trafficking of foamy viruses (FVs) resulting in integration of viral sequences into the host cell genome. The virus encoded glycoprotein harbors all essential viral determinants, which are involved in absorption to the host membrane and triggering the uptake of virus particles. However, only recently light was shed on some details of FV’s interaction with its host cell receptor(s). Latest studies indicate glycosaminoglycans of cellular proteoglycans, particularly heparan sulfate, to be of utmost importance. In a species-specific manner FVs encounter endogenous machineries of the target cell, which are in some cases exploited for fusion and further egress into the cytosol. Mostly triggered by pH-dependent endocytosis, viral and cellular membranes fuse and release naked FV capsids into the cytoplasm. Intact FV capsids are then shuttled along microtubules and are found to accumulate nearby the centrosome where they can remain in a latent state for extended time periods. Depending on the host cell cycle status, FV capsids finally disassemble and, by still poorly characterized mechanisms, the preintegration complex gets access to the host cell chromatin. Host cell mitosis finally allows for viral genome integration, ultimately starting a new round of viral replication." @default.
- W2000322433 created "2016-06-24" @default.
- W2000322433 creator A5017955674 @default.
- W2000322433 creator A5043126037 @default.
- W2000322433 creator A5069357295 @default.
- W2000322433 date "2013-04-08" @default.
- W2000322433 modified "2023-10-01" @default.
- W2000322433 title "Early Events in Foamy Virus—Host Interaction and Intracellular Trafficking" @default.
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- W2000322433 doi "https://doi.org/10.3390/v5041055" @default.
- W2000322433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3705265" @default.