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- W2000322970 abstract "1. Trans-styrylpyridine analogues, which include the most potent known inhibitors of choline acetyltransferase (acetyl-CoA:choline O-acetyltransferase, EC 2.3.1.6), photoisomerize readily in solution to yield mainly the cis isomers. The ionized pyridinium forms are particularly photosensitive. 2. Inhibition of choline acetyltransferase is maximal with the trans isomer of naphthylvinylpyridinium compounds and decreases markedly with progressive isomerization to the cis form. The trans isomer of N-methyl-4-(1-naphthylvinyl)-pyridinium iodide shows an [I50] of 0.65 μM, but an [I50] of 2.7 μM is found if the inhibitor is exposed to indirect daylight for 15 min. 3. With acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) either isomer is inhibitory, the cis form being as potent as, or somewhat more potent than, the trans isomer. 4. Relative light sensitivities of various analogues are consistent with a stabilization of cis isomers by formation of intramolecular charge-transfer complexes." @default.
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- W2000322970 title "Photoisomerization of styrylpyridine analogues in relation to choline acetyltransferase and cholinesterase inhibition" @default.
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- W2000322970 doi "https://doi.org/10.1016/0005-2744(70)90107-5" @default.
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