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- W2000323986 abstract "Dendritic cells (DCs) are key regulators of innate and acquired immunity. The maturation of DCs is directed by signal transduction events downstream of toll-like receptors (TLRs) and other pattern recognition receptors. Here, we demonstrate that, in mouse DCs, TLR agonists stimulate a profound metabolic transition to aerobic glycolysis, similar to the Warburg metabolism displayed by cancer cells. This metabolic switch depends on the phosphatidyl inositol 3'-kinase/Akt pathway, is antagonized by the adenosine monophosphate (AMP)-activated protein kinase (AMPK), and is required for DC maturation. The metabolic switch induced by DC activation is antagonized by the antiinflammatory cytokine interleukin-10. Our data pinpoint TLR-mediated metabolic conversion as essential for DC maturation and function and reveal it as a potential target for intervention in the control of excessive inflammation and inappropriately regulated immune responses." @default.
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- W2000323986 date "2010-06-10" @default.
- W2000323986 modified "2023-10-18" @default.
- W2000323986 title "Toll-like receptor–induced changes in glycolytic metabolism regulate dendritic cell activation" @default.
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- W2000323986 doi "https://doi.org/10.1182/blood-2009-10-249540" @default.
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