FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000324150> ?p ?o ?g. }

• W2000324150 endingPage "5417" @default.
• W2000324150 startingPage "5411" @default.
• W2000324150 abstract "X-ray absorption edge and extended X-ray absorption fine structure (EXAFS) spectra are reported for the Cu(I) and Cu(II) forms of bovine dopamine beta-hydroxylase (DBH; EC 1.14.17.1) and for the Cu(I) form of DBH bound either to tyramine substrate or to a multisubstrate inhibitor [Kruse, L. I., DeWolf, W. E., Jr., Chambers, P. A., & Goodhart, P. J. (1986) Biochemistry 25, 7271-7278]. A significant change in the structure of the copper sites occurs upon ascorbate-mediated reduction of Cu(II) DBH to the Cu(I) form. While the average Cu(II) site most likely consists of a square-planar array of four (N,O)-containing ligands at 1.98 A, the average Cu(I) site shows a reduction in (N,O) coordination number (from approximately 4 to approximately 2) and the addition of a S-containing ligand at 2.30 A. No change in the average Cu(I) ligand environment accompanies binding of tyramine substrate, whereas binding of a multisubstrate inhibitor, 1-(3,5-difluoro-4-hydroxybenzyl)-1H-imidazole-2(3H)-thione, causes an increase in the Cu-S coordination, consistent with inhibitor binding to the Cu(I) site through the S atom. Although excellent signal-to-noise ratio in the EXAFS spectra of ascorbate-reduced DBH facilitated analysis of outer-shell scattering for a Cu..Cu interaction, the presence of a binuclear site could not be proven or disproven due to interference from Cu...C scattering involving the carbons of imidazole ligands." @default.
• W2000324150 created "2016-06-24" @default.
• W2000324150 creator A5026769302 @default.
• W2000324150 creator A5038842958 @default.
• W2000324150 creator A5049878377 @default.
• W2000324150 creator A5067984508 @default.
• W2000324150 creator A5071812338 @default.
• W2000324150 date "1988-07-01" @default.
• W2000324150 modified "2023-09-24" @default.
• W2000324150 title "The copper sites of dopamine .beta.-hydroxylase: an x-ray absorption spectroscopic study" @default.
• W2000324150 cites W1495345528 @default.
• W2000324150 cites W1501093742 @default.
• W2000324150 cites W1541878833 @default.
• W2000324150 cites W1569061157 @default.
• W2000324150 cites W1677557050 @default.
• W2000324150 cites W1696300971 @default.
• W2000324150 cites W1893709048 @default.
• W2000324150 cites W1978155902 @default.
• W2000324150 cites W1984220228 @default.
• W2000324150 cites W1993513520 @default.
• W2000324150 cites W2001841575 @default.
• W2000324150 cites W2004465473 @default.
• W2000324150 cites W2005960152 @default.
• W2000324150 cites W2029365184 @default.
• W2000324150 cites W2030434346 @default.
• W2000324150 cites W2040985975 @default.
• W2000324150 cites W2042003708 @default.
• W2000324150 cites W2045734345 @default.
• W2000324150 cites W2047951761 @default.
• W2000324150 cites W2061229988 @default.
• W2000324150 cites W2065691199 @default.
• W2000324150 cites W2066382752 @default.
• W2000324150 cites W2072166037 @default.
• W2000324150 cites W2079658152 @default.
• W2000324150 cites W2084674052 @default.
• W2000324150 cites W2091601615 @default.
• W2000324150 cites W2100837269 @default.
• W2000324150 cites W2132204205 @default.
• W2000324150 cites W2223862935 @default.
• W2000324150 cites W2411106520 @default.
• W2000324150 cites W2951589754 @default.
• W2000324150 cites W3004480158 @default.
• W2000324150 cites W3005341512 @default.
• W2000324150 cites W3139411305 @default.
• W2000324150 doi "https://doi.org/10.1021/bi00415a005" @default.
• W2000324150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3179263" @default.
• W2000324150 hasPublicationYear "1988" @default.
• W2000324150 type Work @default.
• W2000324150 sameAs 2000324150 @default.
• W2000324150 citedByCount "54" @default.
• W2000324150 countsByYear W20003241502012 @default.
• W2000324150 countsByYear W20003241502013 @default.
• W2000324150 countsByYear W20003241502015 @default.
• W2000324150 countsByYear W20003241502016 @default.
• W2000324150 countsByYear W20003241502020 @default.
• W2000324150 crossrefType "journal-article" @default.
• W2000324150 hasAuthorship W2000324150A5026769302 @default.
• W2000324150 hasAuthorship W2000324150A5038842958 @default.
• W2000324150 hasAuthorship W2000324150A5049878377 @default.
• W2000324150 hasAuthorship W2000324150A5067984508 @default.
• W2000324150 hasAuthorship W2000324150A5071812338 @default.
• W2000324150 hasConcept C107861141 @default.
• W2000324150 hasConcept C11111787 @default.
• W2000324150 hasConcept C111368507 @default.
• W2000324150 hasConcept C115624301 @default.
• W2000324150 hasConcept C116569031 @default.
• W2000324150 hasConcept C119824511 @default.
• W2000324150 hasConcept C121332964 @default.
• W2000324150 hasConcept C125287762 @default.
• W2000324150 hasConcept C127313418 @default.
• W2000324150 hasConcept C159985019 @default.
• W2000324150 hasConcept C170493617 @default.
• W2000324150 hasConcept C178790620 @default.
• W2000324150 hasConcept C185592680 @default.
• W2000324150 hasConcept C192562407 @default.
• W2000324150 hasConcept C2776077682 @default.
• W2000324150 hasConcept C2777289219 @default.
• W2000324150 hasConcept C2780874372 @default.
• W2000324150 hasConcept C544778455 @default.
• W2000324150 hasConcept C55493867 @default.
• W2000324150 hasConcept C62520636 @default.
• W2000324150 hasConcept C71240020 @default.
• W2000324150 hasConcept C8010536 @default.
• W2000324150 hasConceptScore W2000324150C107861141 @default.
• W2000324150 hasConceptScore W2000324150C11111787 @default.
• W2000324150 hasConceptScore W2000324150C111368507 @default.
• W2000324150 hasConceptScore W2000324150C115624301 @default.
• W2000324150 hasConceptScore W2000324150C116569031 @default.
• W2000324150 hasConceptScore W2000324150C119824511 @default.
• W2000324150 hasConceptScore W2000324150C121332964 @default.
• W2000324150 hasConceptScore W2000324150C125287762 @default.
• W2000324150 hasConceptScore W2000324150C127313418 @default.
• W2000324150 hasConceptScore W2000324150C159985019 @default.
• W2000324150 hasConceptScore W2000324150C170493617 @default.
• W2000324150 hasConceptScore W2000324150C178790620 @default.
• W2000324150 hasConceptScore W2000324150C185592680 @default.
• W2000324150 hasConceptScore W2000324150C192562407 @default.
• W2000324150 hasConceptScore W2000324150C2776077682 @default.

• next