Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000324638> ?p ?o ?g. }
- W2000324638 endingPage "450" @default.
- W2000324638 startingPage "437" @default.
- W2000324638 abstract "iNKT cells are innate T lymphocytes recognizing endogenous and foreign lipid antigens presented in the MHC-like molecule CD1d. The semi-invariant iNKT cell TCR can detect certain bacterial and parasitic lipids and drive iNKT cell responses. How iNKT cells respond to fungi, however, is unknown. We found that CD1d-deficient mice, which lack iNKT cells, poorly control infection with the fungal pathogen Aspergillus fumigatus. Furthermore, A. fumigatus rapidly activates iNKT cells in vivo and in vitro in the presence of APCs. Surprisingly, despite a requirement for CD1d recognition, the antifungal iNKT cell response does not require fungal lipids. Instead, Dectin-1- and MyD88-mediated responses to β-1,3 glucans, major fungal cell-wall polysaccharides, trigger IL-12 production by APCs that drives self-reactive iNKT cells to secrete IFN-γ. Innate recognition of β-1,3 glucans also drives iNKT cell responses against Candida, Histoplasma, and Alternaria, suggesting that this mechanism may broadly define the basis for antifungal iNKT cell responses." @default.
- W2000324638 created "2016-06-24" @default.
- W2000324638 creator A5000313790 @default.
- W2000324638 creator A5000815014 @default.
- W2000324638 creator A5003253566 @default.
- W2000324638 creator A5011903299 @default.
- W2000324638 creator A5016293777 @default.
- W2000324638 creator A5019738419 @default.
- W2000324638 creator A5029263589 @default.
- W2000324638 creator A5036703645 @default.
- W2000324638 creator A5048751223 @default.
- W2000324638 creator A5054141043 @default.
- W2000324638 creator A5079564889 @default.
- W2000324638 creator A5080617337 @default.
- W2000324638 date "2011-11-01" @default.
- W2000324638 modified "2023-10-14" @default.
- W2000324638 title "Innate Recognition of Cell Wall β-Glucans Drives Invariant Natural Killer T Cell Responses against Fungi" @default.
- W2000324638 cites W1521459045 @default.
- W2000324638 cites W1593935815 @default.
- W2000324638 cites W1632817771 @default.
- W2000324638 cites W1823151685 @default.
- W2000324638 cites W1962534931 @default.
- W2000324638 cites W1965213225 @default.
- W2000324638 cites W1973040027 @default.
- W2000324638 cites W1973753059 @default.
- W2000324638 cites W1976710853 @default.
- W2000324638 cites W1979775035 @default.
- W2000324638 cites W1980713183 @default.
- W2000324638 cites W1982720299 @default.
- W2000324638 cites W1992523113 @default.
- W2000324638 cites W2002834045 @default.
- W2000324638 cites W2003581234 @default.
- W2000324638 cites W2008415419 @default.
- W2000324638 cites W2008886674 @default.
- W2000324638 cites W2015194963 @default.
- W2000324638 cites W2021215684 @default.
- W2000324638 cites W2022512506 @default.
- W2000324638 cites W2036504193 @default.
- W2000324638 cites W2037539696 @default.
- W2000324638 cites W2039547385 @default.
- W2000324638 cites W2040393349 @default.
- W2000324638 cites W2040768459 @default.
- W2000324638 cites W2043161534 @default.
- W2000324638 cites W2046085625 @default.
- W2000324638 cites W2050428779 @default.
- W2000324638 cites W2050925766 @default.
- W2000324638 cites W2066110878 @default.
- W2000324638 cites W2066222426 @default.
- W2000324638 cites W2069556438 @default.
- W2000324638 cites W2076024275 @default.
- W2000324638 cites W2078807571 @default.
- W2000324638 cites W2080240690 @default.
- W2000324638 cites W2082387759 @default.
- W2000324638 cites W2087044818 @default.
- W2000324638 cites W2090046324 @default.
- W2000324638 cites W2093041058 @default.
- W2000324638 cites W2093862878 @default.
- W2000324638 cites W2096857575 @default.
- W2000324638 cites W2100213157 @default.
- W2000324638 cites W2101233099 @default.
- W2000324638 cites W2102785691 @default.
- W2000324638 cites W2103322081 @default.
- W2000324638 cites W2106435052 @default.
- W2000324638 cites W2108911207 @default.
- W2000324638 cites W2109724505 @default.
- W2000324638 cites W2113311595 @default.
- W2000324638 cites W2119182059 @default.
- W2000324638 cites W2119315539 @default.
- W2000324638 cites W2121477549 @default.
- W2000324638 cites W2125105493 @default.
- W2000324638 cites W2133695261 @default.
- W2000324638 cites W2138738780 @default.
- W2000324638 cites W2140333814 @default.
- W2000324638 cites W2147497666 @default.
- W2000324638 cites W2148442595 @default.
- W2000324638 cites W2151968074 @default.
- W2000324638 cites W2152782116 @default.
- W2000324638 cites W2156580324 @default.
- W2000324638 cites W2158373279 @default.
- W2000324638 cites W2164513774 @default.
- W2000324638 cites W2170417753 @default.
- W2000324638 cites W2403002701 @default.
- W2000324638 doi "https://doi.org/10.1016/j.chom.2011.09.011" @default.
- W2000324638 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5016029" @default.
- W2000324638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22100160" @default.
- W2000324638 hasPublicationYear "2011" @default.
- W2000324638 type Work @default.
- W2000324638 sameAs 2000324638 @default.
- W2000324638 citedByCount "99" @default.
- W2000324638 countsByYear W20003246382012 @default.
- W2000324638 countsByYear W20003246382013 @default.
- W2000324638 countsByYear W20003246382014 @default.
- W2000324638 countsByYear W20003246382015 @default.
- W2000324638 countsByYear W20003246382016 @default.
- W2000324638 countsByYear W20003246382017 @default.
- W2000324638 countsByYear W20003246382018 @default.
- W2000324638 countsByYear W20003246382019 @default.
- W2000324638 countsByYear W20003246382020 @default.