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- W2000324643 abstract "To investigate the associations between CDH1 gene polymorphisms and gastric cancer (GC) risk predisposition.We analyzed four CDH1 polymorphisms (+54 T>C, -160 C>A, -616 G>C, -3159 T>C) in an Omani population, by extraction of genomic DNA from the peripheral blood of 192 patients with GC and 170 control participants and performed CDH1 genotyping using DNA sequencing.CDH1 -160 -AA genotype was associated with an increased risk of GC (OR = 3.6, 95% CI: 1.1-11.8) (P = 0.03). There was no significant association between the other polymorphisms and GC risk. The haplotype analysis of +54 T>C, -160 C>A, -616 G>C, -3159 T>C genotypes revealed that the OR of CCGC and CAGC haplotypes was 1.5 (95% CI: 0.7-3.5) and 1.5 (95% CI: 0.2-3.0), but did not reach statistical significance.The current study suggests that the -160 AA genotype was associated with an increased risk of GC in Oman." @default.
- W2000324643 created "2016-06-24" @default.
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- W2000324643 date "2010-01-01" @default.
- W2000324643 modified "2023-10-16" @default.
- W2000324643 title "Association of<i>E-cadherin</i>(<i>CDH1</i>) gene polymorphisms and gastric cancer risk" @default.
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- W2000324643 doi "https://doi.org/10.3748/wjg.v16.i27.3432" @default.
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