Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000324717> ?p ?o ?g. }
- W2000324717 endingPage "252" @default.
- W2000324717 startingPage "247" @default.
- W2000324717 abstract "It has been shown that the membrane of hybrid NG108-15 neuroblastoma x glioma cells contains a high-affinity binding site for nociceptin. In the present study, we first demonstrated the expression of nociceptin receptor mRNA in NG108-15 cells. Application of nociceptin to NG108-15 cells produced a concentration-dependent (EC50 = 29 nM) inhibition of Ca2+ channel currents in a pertussis toxin-sensitive fashion. This nociceptin-induced inhibition of Ca2+ channel currents was prevented in the presence of omega-conotoxin GVIA, a blocker of the N-type Ca2+ channel, and had both voltage-dependent and -independent components. Prolonged application of nociceptin elicited homologous desensitization of the inhibition with a time constant of 5.3 min. These results indicate that the nociceptin receptor is coupled to the N-type Ca2+ channel via pertussis toxin-sensitive G proteins in NG108-15 cells and that this coupling is associated with rapid and homologous desensitization." @default.
- W2000324717 created "2016-06-24" @default.
- W2000324717 creator A5004477596 @default.
- W2000324717 creator A5026656946 @default.
- W2000324717 creator A5048368425 @default.
- W2000324717 creator A5048854234 @default.
- W2000324717 creator A5078626966 @default.
- W2000324717 creator A5081729913 @default.
- W2000324717 date "1998-06-01" @default.
- W2000324717 modified "2023-09-24" @default.
- W2000324717 title "Nociceptin receptor-mediated Ca2+ channel inhibition and its desensitization in NG108-15 cells" @default.
- W2000324717 cites W1598044684 @default.
- W2000324717 cites W1983702349 @default.
- W2000324717 cites W1991377640 @default.
- W2000324717 cites W1996561349 @default.
- W2000324717 cites W2003581274 @default.
- W2000324717 cites W2013718621 @default.
- W2000324717 cites W2016562510 @default.
- W2000324717 cites W2025841456 @default.
- W2000324717 cites W2026594079 @default.
- W2000324717 cites W2031961444 @default.
- W2000324717 cites W2034595608 @default.
- W2000324717 cites W2034758911 @default.
- W2000324717 cites W2036685400 @default.
- W2000324717 cites W2041157953 @default.
- W2000324717 cites W2045112376 @default.
- W2000324717 cites W2045129357 @default.
- W2000324717 cites W2055246318 @default.
- W2000324717 cites W2056018095 @default.
- W2000324717 cites W2058601469 @default.
- W2000324717 cites W2066624199 @default.
- W2000324717 cites W2074078743 @default.
- W2000324717 cites W2077530921 @default.
- W2000324717 cites W2091459134 @default.
- W2000324717 cites W2126735619 @default.
- W2000324717 cites W2166290059 @default.
- W2000324717 cites W2425057328 @default.
- W2000324717 cites W4302400786 @default.
- W2000324717 doi "https://doi.org/10.1016/s0014-2999(98)00306-9" @default.
- W2000324717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9687009" @default.
- W2000324717 hasPublicationYear "1998" @default.
- W2000324717 type Work @default.
- W2000324717 sameAs 2000324717 @default.
- W2000324717 citedByCount "27" @default.
- W2000324717 countsByYear W20003247172013 @default.
- W2000324717 countsByYear W20003247172014 @default.
- W2000324717 countsByYear W20003247172015 @default.
- W2000324717 countsByYear W20003247172016 @default.
- W2000324717 crossrefType "journal-article" @default.
- W2000324717 hasAuthorship W2000324717A5004477596 @default.
- W2000324717 hasAuthorship W2000324717A5026656946 @default.
- W2000324717 hasAuthorship W2000324717A5048368425 @default.
- W2000324717 hasAuthorship W2000324717A5048854234 @default.
- W2000324717 hasAuthorship W2000324717A5078626966 @default.
- W2000324717 hasAuthorship W2000324717A5081729913 @default.
- W2000324717 hasConcept C125439840 @default.
- W2000324717 hasConcept C12554922 @default.
- W2000324717 hasConcept C126322002 @default.
- W2000324717 hasConcept C134018914 @default.
- W2000324717 hasConcept C153461711 @default.
- W2000324717 hasConcept C153911025 @default.
- W2000324717 hasConcept C170493617 @default.
- W2000324717 hasConcept C185592680 @default.
- W2000324717 hasConcept C2779779143 @default.
- W2000324717 hasConcept C2781063702 @default.
- W2000324717 hasConcept C49773422 @default.
- W2000324717 hasConcept C519063684 @default.
- W2000324717 hasConcept C55493867 @default.
- W2000324717 hasConcept C71924100 @default.
- W2000324717 hasConcept C80631254 @default.
- W2000324717 hasConcept C86803240 @default.
- W2000324717 hasConcept C88016717 @default.
- W2000324717 hasConcept C92759361 @default.
- W2000324717 hasConcept C95444343 @default.
- W2000324717 hasConcept C98274493 @default.
- W2000324717 hasConceptScore W2000324717C125439840 @default.
- W2000324717 hasConceptScore W2000324717C12554922 @default.
- W2000324717 hasConceptScore W2000324717C126322002 @default.
- W2000324717 hasConceptScore W2000324717C134018914 @default.
- W2000324717 hasConceptScore W2000324717C153461711 @default.
- W2000324717 hasConceptScore W2000324717C153911025 @default.
- W2000324717 hasConceptScore W2000324717C170493617 @default.
- W2000324717 hasConceptScore W2000324717C185592680 @default.
- W2000324717 hasConceptScore W2000324717C2779779143 @default.
- W2000324717 hasConceptScore W2000324717C2781063702 @default.
- W2000324717 hasConceptScore W2000324717C49773422 @default.
- W2000324717 hasConceptScore W2000324717C519063684 @default.
- W2000324717 hasConceptScore W2000324717C55493867 @default.
- W2000324717 hasConceptScore W2000324717C71924100 @default.
- W2000324717 hasConceptScore W2000324717C80631254 @default.
- W2000324717 hasConceptScore W2000324717C86803240 @default.
- W2000324717 hasConceptScore W2000324717C88016717 @default.
- W2000324717 hasConceptScore W2000324717C92759361 @default.
- W2000324717 hasConceptScore W2000324717C95444343 @default.
- W2000324717 hasConceptScore W2000324717C98274493 @default.
- W2000324717 hasFunder F4320320912 @default.
- W2000324717 hasIssue "2" @default.
- W2000324717 hasLocation W20003247171 @default.