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- W2000324984 abstract "Recent advances in molecular and computational biology have revolutionized ways of addressing questions relating to the identification of targets for antiparasite agents. The wealth of information available to the public has revealed new opportunities in disciplines ranging from cell and developmental biology to drug and vaccine development and pharmacogenomics. Several different high-throughput techniques allowing the study of differential gene expression have been developed, including comparative expressed sequence tag (EST; short single-pass DNA sequences obtained from either end of cDNA clones) sequencing, differential display, serial analysis of gene expression (SAGE) and the DNA chip or microarray technology. Functional genomics and proteomics are promising tools in the search for reagents against pathogens 1 Gutierrez J.A Genomics: from novel genes to new therapeutics in parasitology. Int. J. Parasitol. 2000; 30: 247-252 Crossref PubMed Scopus (22) Google Scholar . Proteomics-based research is however plagued by technical drawbacks (such as the need for specialized equipment, poor protein resolution and detection) that need to be resolved before it can become as ‘user-friendly’, large-scale and highly automated as genomics. Meanwhile, parasite genome analysis still represents a key factor in identifying new targets for drug, vaccine and diagnostics development, as well as dissecting the biological basis of drug resistance, antigenic diversity, infectivity and pathology." @default.
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- W2000324984 date "2001-04-01" @default.
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- W2000324984 title "Identification of filarial vaccine and drug target candidates by EST analysis" @default.
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- W2000324984 doi "https://doi.org/10.1016/s1471-4922(00)01875-4" @default.
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