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- W2000328346 abstract "To determine whether a low fat diet supplemented with omega-3 positively affects quality of life (QOL) in relapsing-remitting MS (RRMS) patients. In this 1-year long double-blind, randomized trial, patients were randomized to two dietary interventions: the Fish Oil (FO) group received a low fat diet (15% fat) with omega-3 FOs and the Olive Oil (OO) group received the AHA Step I diet (fat 30%) with OO supplements. The primary outcome measure was the Physical Components Summary Scale (PCS) of the Short Health Status Questionnaire (SF-36). Additional measures using MS specific QOL questionnaires, neurological status and relapse rate were obtained.31 RRMS patients were enrolled, with mean follow up over 11 +/- SD 2.9 months. Clinical benefits favoring the FO group were observed on PCS/SF-36 (P = 0.050) and MHI (P = 0.050) at 6 months. Reduced fatigue was seen on the OO diet at 6 months (P = 0.035). The relapse rate decreased in both groups relative to the rates during the 1 year preceding the study: mean change in relapse rate in the FO group: -0.79 +/- SD 1.12 relapses/year (P = 0.021) vs. -0.69 +/- SD 1.11 (P = 0.044) in the OO group. This study suggests that a low fat diet supplemented with omega-3 PUFA can have moderate benefits in RRMS patients on concurrent disease modifying therapies." @default.
- W2000328346 created "2016-06-24" @default.
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- W2000328346 date "2005-11-01" @default.
- W2000328346 modified "2023-10-17" @default.
- W2000328346 title "Low fat dietary intervention with ω-3 fatty acid supplementation in multiple sclerosis patients" @default.
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- W2000328346 doi "https://doi.org/10.1016/j.plefa.2005.05.024" @default.
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