FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000330269> ?p ?o ?g. }

• W2000330269 endingPage "54" @default.
• W2000330269 startingPage "48" @default.
• W2000330269 abstract "This study was aimed to identify the monocarboxylate transporters (MCTs) in HeLa cells and to delineate their role in transportation of l-lactic acid. The functional role of MCTs in lactic acid transport was evaluated at various mucosal pHs (4.5–7.4) or in the presence of various loading doses (0.2–2 mM) of lactic acid, MCT substrates (nicotinic acid, n-butyric acid, etc.) and inhibitors (α-cyano-4-hydroxycinnamate and para-chloromercuribenzoic acid). The molecular properties of MCTs were characterized using reverse transcription-polymerase chain reaction (RT-PCR). The uptake rate of lactic acid by HeLa cells significantly increased from 0.353 ± 0.052 to 1.103 ± 0.196 μmol/mg protein as the extra-cellular pH changed from 7.4 to 4.5, indicating that activities of MCT were mediated through H+-linked mechanism. The uptake profile of lactic acid followed the saturable process with the Km value of 0.53 mM. The uptake rate of lactic acid is concentration dependent and is reduced in the presence of MCT inhibitors. MCT isoforms 1, 5 and 6 in HeLa cells were identified by RT-PCR. HeLa cell line can be used as an effective screening tool for intravaginally administered drugs targeted toward MCT." @default.
• W2000330269 created "2016-06-24" @default.
• W2000330269 creator A5011255175 @default.
• W2000330269 creator A5017092656 @default.
• W2000330269 creator A5022658963 @default.
• W2000330269 date "2006-11-01" @default.
• W2000330269 modified "2023-09-26" @default.
• W2000330269 title "The role of monocarboxylate transporters in uptake of lactic acid in HeLa cells" @default.
• W2000330269 cites W1601678499 @default.
• W2000330269 cites W184887858 @default.
• W2000330269 cites W1849470447 @default.
• W2000330269 cites W1900054156 @default.
• W2000330269 cites W1901615681 @default.
• W2000330269 cites W1906860528 @default.
• W2000330269 cites W1969648248 @default.
• W2000330269 cites W1972510286 @default.
• W2000330269 cites W1977179183 @default.
• W2000330269 cites W1984028198 @default.
• W2000330269 cites W2000541190 @default.
• W2000330269 cites W2001176512 @default.
• W2000330269 cites W2008182673 @default.
• W2000330269 cites W2034602230 @default.
• W2000330269 cites W2050165413 @default.
• W2000330269 cites W2060092504 @default.
• W2000330269 cites W2060669952 @default.
• W2000330269 cites W2067548955 @default.
• W2000330269 cites W2075633231 @default.
• W2000330269 cites W2078708876 @default.
• W2000330269 cites W2083101998 @default.
• W2000330269 cites W2092016012 @default.
• W2000330269 cites W2104310413 @default.
• W2000330269 cites W2106532277 @default.
• W2000330269 cites W2130910482 @default.
• W2000330269 cites W2170261518 @default.
• W2000330269 cites W2187950387 @default.
• W2000330269 cites W2405493074 @default.
• W2000330269 cites W345827556 @default.
• W2000330269 cites W4234496344 @default.
• W2000330269 cites W4294216491 @default.
• W2000330269 doi "https://doi.org/10.1016/j.ijpharm.2006.06.018" @default.
• W2000330269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16887304" @default.
• W2000330269 hasPublicationYear "2006" @default.
• W2000330269 type Work @default.
• W2000330269 sameAs 2000330269 @default.
• W2000330269 citedByCount "19" @default.
• W2000330269 countsByYear W20003302692013 @default.
• W2000330269 countsByYear W20003302692014 @default.
• W2000330269 countsByYear W20003302692015 @default.
• W2000330269 countsByYear W20003302692016 @default.
• W2000330269 countsByYear W20003302692017 @default.
• W2000330269 countsByYear W20003302692018 @default.
• W2000330269 countsByYear W20003302692019 @default.
• W2000330269 countsByYear W20003302692020 @default.
• W2000330269 countsByYear W20003302692021 @default.
• W2000330269 countsByYear W20003302692022 @default.
• W2000330269 crossrefType "journal-article" @default.
• W2000330269 hasAuthorship W2000330269A5011255175 @default.
• W2000330269 hasAuthorship W2000330269A5017092656 @default.
• W2000330269 hasAuthorship W2000330269A5022658963 @default.
• W2000330269 hasConcept C104317684 @default.
• W2000330269 hasConcept C149011108 @default.
• W2000330269 hasConcept C1491633281 @default.
• W2000330269 hasConcept C153911025 @default.
• W2000330269 hasConcept C185592680 @default.
• W2000330269 hasConcept C2775920511 @default.
• W2000330269 hasConcept C2777366897 @default.
• W2000330269 hasConcept C2779843069 @default.
• W2000330269 hasConcept C2781217356 @default.
• W2000330269 hasConcept C523546767 @default.
• W2000330269 hasConcept C54355233 @default.
• W2000330269 hasConcept C55493867 @default.
• W2000330269 hasConcept C86803240 @default.
• W2000330269 hasConceptScore W2000330269C104317684 @default.
• W2000330269 hasConceptScore W2000330269C149011108 @default.
• W2000330269 hasConceptScore W2000330269C1491633281 @default.
• W2000330269 hasConceptScore W2000330269C153911025 @default.
• W2000330269 hasConceptScore W2000330269C185592680 @default.
• W2000330269 hasConceptScore W2000330269C2775920511 @default.
• W2000330269 hasConceptScore W2000330269C2777366897 @default.
• W2000330269 hasConceptScore W2000330269C2779843069 @default.
• W2000330269 hasConceptScore W2000330269C2781217356 @default.
• W2000330269 hasConceptScore W2000330269C523546767 @default.
• W2000330269 hasConceptScore W2000330269C54355233 @default.
• W2000330269 hasConceptScore W2000330269C55493867 @default.
• W2000330269 hasConceptScore W2000330269C86803240 @default.
• W2000330269 hasIssue "1-2" @default.
• W2000330269 hasLocation W20003302691 @default.
• W2000330269 hasLocation W20003302692 @default.
• W2000330269 hasOpenAccess W2000330269 @default.
• W2000330269 hasPrimaryLocation W20003302691 @default.
• W2000330269 hasRelatedWork W2000330269 @default.
• W2000330269 hasRelatedWork W2056729660 @default.
• W2000330269 hasRelatedWork W2142455113 @default.
• W2000330269 hasRelatedWork W2170601242 @default.
• W2000330269 hasRelatedWork W2272331078 @default.
• W2000330269 hasRelatedWork W2356084217 @default.
• W2000330269 hasRelatedWork W2392820081 @default.
• W2000330269 hasRelatedWork W2416681792 @default.

• next