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- W2000330629 abstract "Ethane dimethanesulfonate (EDS), a well-known alkylating agent, selectively destroys Leydig cells. To clarify the molecular pathways underlying EDS action on Leydig cells, we analyzed gene expression profiles of an EDS-treated TM3 Leydig cell line. In this study, we analyzed the representative canonical pathways and toxicity pathways/gene lists using the Ingenuity Pathways Analysis program. In TM3 cells, 677 and 6756 genes were identified as being up- or downregulated after 3 and 24 h EDS treatments, respectively, (>1.3-fold changes, p < 0.05). Toxicological pathway analysis revealed that expression of genes related to Nrf2-mediated oxidative stress response showed remarkable changes in early or later stage of EDS-treated TM3 cells. Several genes related to steroidogenesis and apoptosis were also differentially expressed at 24 h in EDS-treated TM3 cells. Overall, toxicological pathway analysis using gene expression profiling showed that oxidative stress might be an important factor in cell death in TM3 cells affected by EDS treatment." @default.
- W2000330629 created "2016-06-24" @default.
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- W2000330629 date "2012-06-01" @default.
- W2000330629 modified "2023-09-27" @default.
- W2000330629 title "Gene expression analysis of toxicological pathways in TM3 leydig cell lines treated with Ethane dimethanesulfonate" @default.
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- W2000330629 doi "https://doi.org/10.1002/jbt.21409" @default.
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