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- W2000331018 abstract "Annexin 2 binds and aggregates biological membranes in a Ca2+-dependent manner. This protein exists as a monomer (p36) or as a heterotetramer (p90) in which two p36 chains are associated with a dimer of p11, a member of the S100 protein family. Protein kinase C phosphorylates the protein at the level of the N-terminal tail on serines 11 and 25, thereby modifying its oligomeric structure and its properties of membrane aggregation. To analyze these effects, the properties of a series of mutants in which serines 11 and 25 were replaced by alanine and/or glutamic acid were investigated. The affinity for p11 light chain was decreased in the S11E mutants. Glutamic acid residues in positions 11 or 25 did not change membrane binding, either in the tetrameric or in the monomeric form. On the other hand, these mutations affected the aggregation properties of the two forms. For the tetramer, the aggregation efficiency was decreased but not the Ca2+ sensitivity, whereas the latter was affected in the case of the monomer. The effects were stronger in the S11E mutants, and they were cumulative in the double mutant. They suggest a different conformation of the N-terminal domain in the mutants (and in the phosphorylated protein), a hypothesis which is supported by proteolysis experiments. This conformational change would affect aggregation by the monomer through a dimerization step." @default.
- W2000331018 created "2016-06-24" @default.
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- W2000331018 date "2000-11-14" @default.
- W2000331018 modified "2023-09-26" @default.
- W2000331018 title "N-Terminal Domain of Annexin 2 Regulates Ca<sup>2+</sup>-Dependent Membrane Aggregation by the Core Domain: A Site Directed Mutagenesis Study" @default.
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- W2000331018 doi "https://doi.org/10.1021/bi000764r" @default.
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