FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000331470> ?p ?o ?g. }

• W2000331470 endingPage "3049" @default.
• W2000331470 startingPage "3043" @default.
• W2000331470 abstract "Human sulfite oxidase (hSO), an essential molybdoheme enzyme, catalyzes the oxidation of toxic sulfite to sulfate. The proposed catalytic cycle includes two, one-electron intramolecular electron transfers (IET) between the molybdenum (Mo) and the heme domains. Rapid IET rates are ascribed to conformational changes that bring the two domains into close proximity to one another. Previous studies of hSO have focused on the roles of conserved residues near the Mo active site and on the tether that links the two domains. Here four aromatic surface residues on the heme domain (phenylalanine 57 (F57), phenylalanine 79 (F79), tyrosine 83 (Y83), and histidine 90 (H90)) have been mutated, and their involvement in IET rates, the heme midpoint potential, and the catalytic activity of hSO have been investigated using laser flash photolysis, spectroelectrochemistry, and steady-state kinetics, respectively. The results indicate that the size and hydrophobicity of F57 play an important role in modulating the heme potential and that F57 also affects the IET rates. The data also suggest that important interactions of H90 with a heme propionate group destabilize the Fe(III) state of the heme. The positive charge on H90 at pH ≤ 7.0 may decrease the electrostatic interaction between the Mo and heme domains, thereby decreasing the IET rates of wt hSO at low pH. Lastly, mutations of F79 and Y83, which are located on the surface of the heme domain, but not in direct contact with the heme or the propionate groups, have little effect on either IET or the heme potential." @default.
• W2000331470 created "2016-06-24" @default.
• W2000331470 creator A5001589879 @default.
• W2000331470 creator A5011650766 @default.
• W2000331470 creator A5012627839 @default.
• W2000331470 creator A5018957391 @default.
• W2000331470 creator A5041376191 @default.
• W2000331470 creator A5050493538 @default.
• W2000331470 creator A5050668845 @default.
• W2000331470 date "2013-01-01" @default.
• W2000331470 modified "2023-09-23" @default.
• W2000331470 title "Effects of mutating aromatic surface residues of the heme domain of human sulfite oxidase on its heme midpoint potential, intramolecular electron transfer, and steady-state kinetics" @default.
• W2000331470 cites W1510741760 @default.
• W2000331470 cites W1552986092 @default.
• W2000331470 cites W1596776815 @default.
• W2000331470 cites W1964263291 @default.
• W2000331470 cites W1977380645 @default.
• W2000331470 cites W1978539412 @default.
• W2000331470 cites W1980316187 @default.
• W2000331470 cites W1988727220 @default.
• W2000331470 cites W1990274831 @default.
• W2000331470 cites W1995418731 @default.
• W2000331470 cites W1995461790 @default.
• W2000331470 cites W1997734693 @default.
• W2000331470 cites W2002513815 @default.
• W2000331470 cites W2002649716 @default.
• W2000331470 cites W2006879511 @default.
• W2000331470 cites W2010901060 @default.
• W2000331470 cites W2013011921 @default.
• W2000331470 cites W2018621176 @default.
• W2000331470 cites W2019005299 @default.
• W2000331470 cites W2022948031 @default.
• W2000331470 cites W2031189321 @default.
• W2000331470 cites W2031587301 @default.
• W2000331470 cites W2032210330 @default.
• W2000331470 cites W2045426200 @default.
• W2000331470 cites W2060594976 @default.
• W2000331470 cites W2064852917 @default.
• W2000331470 cites W2068762318 @default.
• W2000331470 cites W2071595256 @default.
• W2000331470 cites W2072427973 @default.
• W2000331470 cites W2075788971 @default.
• W2000331470 cites W2086347059 @default.
• W2000331470 cites W2140901473 @default.
• W2000331470 cites W2166125670 @default.
• W2000331470 cites W2167623519 @default.
• W2000331470 cites W4245399940 @default.
• W2000331470 cites W48899089 @default.
• W2000331470 doi "https://doi.org/10.1039/c2dt31508d" @default.
• W2000331470 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22975842" @default.
• W2000331470 hasPublicationYear "2013" @default.
• W2000331470 type Work @default.
• W2000331470 sameAs 2000331470 @default.
• W2000331470 citedByCount "6" @default.
• W2000331470 countsByYear W20003314702013 @default.
• W2000331470 countsByYear W20003314702014 @default.
• W2000331470 countsByYear W20003314702017 @default.
• W2000331470 countsByYear W20003314702023 @default.
• W2000331470 crossrefType "journal-article" @default.
• W2000331470 hasAuthorship W2000331470A5001589879 @default.
• W2000331470 hasAuthorship W2000331470A5011650766 @default.
• W2000331470 hasAuthorship W2000331470A5012627839 @default.
• W2000331470 hasAuthorship W2000331470A5018957391 @default.
• W2000331470 hasAuthorship W2000331470A5041376191 @default.
• W2000331470 hasAuthorship W2000331470A5050493538 @default.
• W2000331470 hasAuthorship W2000331470A5050668845 @default.
• W2000331470 hasConcept C123669783 @default.
• W2000331470 hasConcept C161790260 @default.
• W2000331470 hasConcept C181199279 @default.
• W2000331470 hasConcept C185592680 @default.
• W2000331470 hasConcept C197957613 @default.
• W2000331470 hasConcept C2776217839 @default.
• W2000331470 hasConcept C2777998628 @default.
• W2000331470 hasConcept C2778460671 @default.
• W2000331470 hasConcept C2779830873 @default.
• W2000331470 hasConcept C2780014933 @default.
• W2000331470 hasConcept C41183919 @default.
• W2000331470 hasConcept C55493867 @default.
• W2000331470 hasConcept C71240020 @default.
• W2000331470 hasConcept C75079739 @default.
• W2000331470 hasConcept C75473681 @default.
• W2000331470 hasConceptScore W2000331470C123669783 @default.
• W2000331470 hasConceptScore W2000331470C161790260 @default.
• W2000331470 hasConceptScore W2000331470C181199279 @default.
• W2000331470 hasConceptScore W2000331470C185592680 @default.
• W2000331470 hasConceptScore W2000331470C197957613 @default.
• W2000331470 hasConceptScore W2000331470C2776217839 @default.
• W2000331470 hasConceptScore W2000331470C2777998628 @default.
• W2000331470 hasConceptScore W2000331470C2778460671 @default.
• W2000331470 hasConceptScore W2000331470C2779830873 @default.
• W2000331470 hasConceptScore W2000331470C2780014933 @default.
• W2000331470 hasConceptScore W2000331470C41183919 @default.
• W2000331470 hasConceptScore W2000331470C55493867 @default.
• W2000331470 hasConceptScore W2000331470C71240020 @default.
• W2000331470 hasConceptScore W2000331470C75079739 @default.
• W2000331470 hasConceptScore W2000331470C75473681 @default.
• W2000331470 hasIssue "9" @default.
• W2000331470 hasLocation W20003314701 @default.

• next