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- W2000332908 abstract "ABSTRACT Objective To describe 3 different scenarios of reversible hypothyroidism in young patients with adrenal insufficiency. Methods We present 3 case reports of patients with adrenal insufficiency—one with delayed puberty, the second with type 1 diabetes and poor weight gain, and the third with hypoglycemia-related seizures and glucocorticoid deficiency—who had biochemical evidence of hypothyroidism. Results Our first patient (case 1) initially had a mildly elevated thyrotropin (thyroid-stimulating hormone or TSH) level and a normal free thyroxine (FT4) level that, on follow-up assessment, had progressed to persistent mild elevation of TSH and low FT4 concentration. The other 2 patients (cases 2 and 3) had low FT4 and mildly elevated TSH values at the time of diagnosis of adrenal insufficiency. In all 3 patients, the results of thyroid function tests normalized with use of physiologic doses of adrenal hormone replacement therapy, without thyroid hormone replacement. All 3 patients remained euthyroid after 4, 3, and 1 year of follow-up, respectively. Conclusion These observations add insights into the complexities of the thyroadrenal interactions. These examples are important because thyroid hormone replacement in the setting of adrenal insufficiency could be unwarranted. (Endocr Pract. 2006;12:572-575)" @default.
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- W2000332908 date "2006-09-01" @default.
- W2000332908 modified "2023-10-16" @default.
- W2000332908 title "Reversible Subclinical Hypothyroidism in the Presence of Adrenal Insufficiency" @default.
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- W2000332908 doi "https://doi.org/10.4158/ep.12.5.572" @default.
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