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• W2000333516 abstract "Background Hyaluronic acid (HA) provides a long-lasting and distinct mucosal elevation for EMR, but expense and inconvenience have limited its adoption. Objective To evaluate the safety and efficacy of an over-the-counter 0.15% HA preparation for EMR. Design Retrospective study. Setting Veterans Administration Hospital and university hospital. Patients 30 patients with a total of 32 colonic lesions and 1 duodenal lesion. Intervention EMR by using HA. Main Outcome Measurements En bloc resection rate and complications. Results EMR was successful in all cases. En bloc resection was achieved in 26 of the 28 lesions up to 25 mm in diameter. Two lesions, both with fibrosis from prior attempted resection, had trace residual tissue necessitating cauterization with argon plasma. Five lesions measuring 30 mm to 60 mm all required piecemeal resection. There was one complication, a postpolypectomy bleed. Limitations Small number of patients and retrospective design. Conclusions EMR may be performed safely and effectively by using an inexpensive, over-the-counter 0.15% HA preparation. Further studies are needed to verify the results of this study and to compare the safety and efficacy of this HA preparation with saline solution. Hyaluronic acid (HA) provides a long-lasting and distinct mucosal elevation for EMR, but expense and inconvenience have limited its adoption. To evaluate the safety and efficacy of an over-the-counter 0.15% HA preparation for EMR. Retrospective study. Veterans Administration Hospital and university hospital. 30 patients with a total of 32 colonic lesions and 1 duodenal lesion. EMR by using HA. En bloc resection rate and complications. EMR was successful in all cases. En bloc resection was achieved in 26 of the 28 lesions up to 25 mm in diameter. Two lesions, both with fibrosis from prior attempted resection, had trace residual tissue necessitating cauterization with argon plasma. Five lesions measuring 30 mm to 60 mm all required piecemeal resection. There was one complication, a postpolypectomy bleed. Small number of patients and retrospective design. EMR may be performed safely and effectively by using an inexpensive, over-the-counter 0.15% HA preparation. Further studies are needed to verify the results of this study and to compare the safety and efficacy of this HA preparation with saline solution." @default.
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• W2000333516 date "2012-05-01" @default.
• W2000333516 modified "2023-09-23" @default.
• W2000333516 title "Endoscopic mucosal resection with an over-the-counter hyaluronate preparation" @default.
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• W2000333516 doi "https://doi.org/10.1016/j.gie.2012.01.010" @default.
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