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• W2000334080 startingPage "131" @default.
• W2000334080 abstract "Human complement regulatory (also called inhibitory) proteins control misdirected attack of complement against autologous cells. Trypanosome and schistosome parasites which survive in the host vascular system also possess regulators of human complement. We have shown Sh-TOR, a protein with three predicted transmembrane domains, located on the Schistosoma parasite surface, to be a novel complement regulatory receptor. The N-terminal extracellular domain, Sh-TOR-ed1, binds the complement protein C2 from human serum and specifically interacts with the C2a fragment. As a result Sh-TOR-ed1 pre-incubated with C2 inhibits classical pathway (CP)-mediated haemolysis of sheep erythrocytes in a dose-dependent manner. In CP-mediated complement activation, C2 normally binds to C4b to form the CP C3 convertase and Sh-TOR-ed1 has short regions of sequence identity with a segment of human C4b. We propose the more appropriate name for TOR of CRIT (complement C2 receptor inhibitory trispanning)." @default.
• W2000334080 created "2016-06-24" @default.
• W2000334080 creator A5029330042 @default.
• W2000334080 creator A5045570551 @default.
• W2000334080 date "2000-03-20" @default.
• W2000334080 modified "2023-09-26" @default.
• W2000334080 title "A<i>Schistosoma</i>protein, Sh-TOR, is a novel inhibitor of complement which binds human C2" @default.
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• W2000334080 doi "https://doi.org/10.1016/s0014-5793(00)01304-1" @default.
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