Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000334444> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2000334444 endingPage "86" @default.
- W2000334444 startingPage "73" @default.
- W2000334444 abstract "Previous work had implicated T cells within the stimulating population as having a significant role in the MLR. We now report that depletion of T cells from the stimulators caused a reduction in proliferative response in mixed leukocyte reaction (MLR) by 50% or more. This response could be restored by adding T-enriched cells from the stimulators but not from the responders. During MLR, the T-cells in the stimulating population demonstrated changes characteristic of early activation, namely, increase in RNA synthesis. Stimulator T-cells have been shown to regulate the interleukin 2 (IL 2) production in mixed leukocyte culture (MLC). Depletion of T cells from the stimulators reduced the level of IL 2 in the culture. Addition of IL 2 to the cultures containing T-depleted stimulators reconstituted the proliferative response. Our data suggest that there may be alternative ways of producing IL 2-like growth factors. Depletion of T cells from the stimulators allows the detection of a growth factor which differs from IL 2 in its mode of production. We conclude that optimal proliferation in the MLR requires that the stimulating population contain T cells which regulate the growth factors in the culture." @default.
- W2000334444 created "2016-06-24" @default.
- W2000334444 creator A5041357908 @default.
- W2000334444 creator A5048866661 @default.
- W2000334444 creator A5076996005 @default.
- W2000334444 date "1986-01-01" @default.
- W2000334444 modified "2023-09-23" @default.
- W2000334444 title "Stimulator T-Cells and the Regulation of Growth Factors Produced in the Murine Mixed Leukocyte Reaction" @default.
- W2000334444 cites W1973376649 @default.
- W2000334444 cites W1976046966 @default.
- W2000334444 cites W1976267000 @default.
- W2000334444 cites W1985800839 @default.
- W2000334444 cites W2033065327 @default.
- W2000334444 cites W2041364299 @default.
- W2000334444 cites W2056602434 @default.
- W2000334444 cites W2056760230 @default.
- W2000334444 cites W2074614649 @default.
- W2000334444 cites W2093473323 @default.
- W2000334444 cites W2165997648 @default.
- W2000334444 doi "https://doi.org/10.3109/08820138609042020" @default.
- W2000334444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2940180" @default.
- W2000334444 hasPublicationYear "1986" @default.
- W2000334444 type Work @default.
- W2000334444 sameAs 2000334444 @default.
- W2000334444 citedByCount "0" @default.
- W2000334444 crossrefType "journal-article" @default.
- W2000334444 hasAuthorship W2000334444A5041357908 @default.
- W2000334444 hasAuthorship W2000334444A5048866661 @default.
- W2000334444 hasAuthorship W2000334444A5076996005 @default.
- W2000334444 hasConcept C129374314 @default.
- W2000334444 hasConcept C131665280 @default.
- W2000334444 hasConcept C153911025 @default.
- W2000334444 hasConcept C154317977 @default.
- W2000334444 hasConcept C185592680 @default.
- W2000334444 hasConcept C202751555 @default.
- W2000334444 hasConcept C203014093 @default.
- W2000334444 hasConcept C2776090121 @default.
- W2000334444 hasConcept C2777371288 @default.
- W2000334444 hasConcept C2778690821 @default.
- W2000334444 hasConcept C2778740727 @default.
- W2000334444 hasConcept C2908647359 @default.
- W2000334444 hasConcept C39347974 @default.
- W2000334444 hasConcept C55493867 @default.
- W2000334444 hasConcept C71924100 @default.
- W2000334444 hasConcept C86803240 @default.
- W2000334444 hasConcept C8891405 @default.
- W2000334444 hasConcept C95444343 @default.
- W2000334444 hasConcept C99454951 @default.
- W2000334444 hasConceptScore W2000334444C129374314 @default.
- W2000334444 hasConceptScore W2000334444C131665280 @default.
- W2000334444 hasConceptScore W2000334444C153911025 @default.
- W2000334444 hasConceptScore W2000334444C154317977 @default.
- W2000334444 hasConceptScore W2000334444C185592680 @default.
- W2000334444 hasConceptScore W2000334444C202751555 @default.
- W2000334444 hasConceptScore W2000334444C203014093 @default.
- W2000334444 hasConceptScore W2000334444C2776090121 @default.
- W2000334444 hasConceptScore W2000334444C2777371288 @default.
- W2000334444 hasConceptScore W2000334444C2778690821 @default.
- W2000334444 hasConceptScore W2000334444C2778740727 @default.
- W2000334444 hasConceptScore W2000334444C2908647359 @default.
- W2000334444 hasConceptScore W2000334444C39347974 @default.
- W2000334444 hasConceptScore W2000334444C55493867 @default.
- W2000334444 hasConceptScore W2000334444C71924100 @default.
- W2000334444 hasConceptScore W2000334444C86803240 @default.
- W2000334444 hasConceptScore W2000334444C8891405 @default.
- W2000334444 hasConceptScore W2000334444C95444343 @default.
- W2000334444 hasConceptScore W2000334444C99454951 @default.
- W2000334444 hasIssue "1" @default.
- W2000334444 hasLocation W20003344441 @default.
- W2000334444 hasLocation W20003344442 @default.
- W2000334444 hasOpenAccess W2000334444 @default.
- W2000334444 hasPrimaryLocation W20003344441 @default.
- W2000334444 hasRelatedWork W1989383189 @default.
- W2000334444 hasRelatedWork W2002809032 @default.
- W2000334444 hasRelatedWork W2052493267 @default.
- W2000334444 hasRelatedWork W2072502005 @default.
- W2000334444 hasRelatedWork W2072972124 @default.
- W2000334444 hasRelatedWork W2084375868 @default.
- W2000334444 hasRelatedWork W2111487644 @default.
- W2000334444 hasRelatedWork W2139860153 @default.
- W2000334444 hasRelatedWork W2148785609 @default.
- W2000334444 hasRelatedWork W2417599370 @default.
- W2000334444 hasVolume "15" @default.
- W2000334444 isParatext "false" @default.
- W2000334444 isRetracted "false" @default.
- W2000334444 magId "2000334444" @default.
- W2000334444 workType "article" @default.