Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000334785> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2000334785 endingPage "650" @default.
- W2000334785 startingPage "641" @default.
- W2000334785 abstract "The antinociceptive, cardiovascular, and autonomic nervous system actions of [D-Ala2]-methionine enkephalinamide (DALA) were assessed in conscious and pentobarbital-anesthetized rats. Intravenous administration of DALA inhibited the tail-flick reflex evoked by noxious radiant heat in both conscious and pentobarbital-anesthetized rats. In general, the magnitude of the inhibition was not significantly affected by the presence of pentobarbital-anesthesia. DALA also induced hypotension and bradycardia in these rats, but these responses were significantly attenuated by pentobarbital-anesthesia. Arterial blood flows were initially decreased and vascular resistances increased in mesenteric, renal, and hindquarter beds following DALA administration, but these parameters rapidly returned to baseline levels except in the hindquarter bed where flows increased significantly above baseline levels. All of the changes in blood flows were significantly greater in conscious compared to pentobarbital-anesthetized rats. In intact pentobarbital-anesthetized rats, DALA induced inhibition of renal sympathetic nerve activity. However, DALA induced a pressor response with a brief increase in renal sympathetic nerve activity in rats with bilateral vagotomy. Similarly, in the conscious rat with ganglionic blockade, DALA induces a brief pressor response. These outcomes indicate that the brief hypotension observed in the intact rat following administration of DALA is probably the net outcome of a large vagally-induced decrease in sympathetic tone and a small increase in sympathetic tone of either neurogenic or peripheral origin. These outcomes are discussed in terms of cardiovascular-somatosensory interactions." @default.
- W2000334785 created "2016-06-24" @default.
- W2000334785 creator A5024942419 @default.
- W2000334785 creator A5068764655 @default.
- W2000334785 date "1986-09-01" @default.
- W2000334785 modified "2023-09-27" @default.
- W2000334785 title "[D-Ala2]-methionine enkephalinamide (DALA): Characterization of antinociceptive, cardiovascular, and autonomic nervous system actions in conscious and pentobarbital-anesthetized rats" @default.
- W2000334785 cites W1512093443 @default.
- W2000334785 cites W1964931621 @default.
- W2000334785 cites W1965166997 @default.
- W2000334785 cites W1971232468 @default.
- W2000334785 cites W1974742465 @default.
- W2000334785 cites W1979695027 @default.
- W2000334785 cites W1979777919 @default.
- W2000334785 cites W1994035275 @default.
- W2000334785 cites W1994392334 @default.
- W2000334785 cites W1998837567 @default.
- W2000334785 cites W2012253976 @default.
- W2000334785 cites W2017058118 @default.
- W2000334785 cites W2032472489 @default.
- W2000334785 cites W2036628933 @default.
- W2000334785 cites W2037994619 @default.
- W2000334785 cites W2044579233 @default.
- W2000334785 cites W2046302138 @default.
- W2000334785 cites W2049458108 @default.
- W2000334785 cites W2055211686 @default.
- W2000334785 cites W2057420680 @default.
- W2000334785 cites W2075016390 @default.
- W2000334785 cites W2076211204 @default.
- W2000334785 cites W2078012587 @default.
- W2000334785 cites W2078683640 @default.
- W2000334785 cites W2079704502 @default.
- W2000334785 cites W2082311341 @default.
- W2000334785 cites W2083865582 @default.
- W2000334785 cites W2095341323 @default.
- W2000334785 cites W2114382165 @default.
- W2000334785 cites W2140285237 @default.
- W2000334785 cites W2148172817 @default.
- W2000334785 cites W2247075459 @default.
- W2000334785 cites W2343564213 @default.
- W2000334785 cites W2405092680 @default.
- W2000334785 cites W2411853216 @default.
- W2000334785 cites W2416110368 @default.
- W2000334785 doi "https://doi.org/10.1016/0091-3057(86)90154-1" @default.
- W2000334785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3774831" @default.
- W2000334785 hasPublicationYear "1986" @default.
- W2000334785 type Work @default.
- W2000334785 sameAs 2000334785 @default.
- W2000334785 citedByCount "12" @default.
- W2000334785 crossrefType "journal-article" @default.
- W2000334785 hasAuthorship W2000334785A5024942419 @default.
- W2000334785 hasAuthorship W2000334785A5068764655 @default.
- W2000334785 hasConcept C126322002 @default.
- W2000334785 hasConcept C134018914 @default.
- W2000334785 hasConcept C15490471 @default.
- W2000334785 hasConcept C170493617 @default.
- W2000334785 hasConcept C24998067 @default.
- W2000334785 hasConcept C2776755955 @default.
- W2000334785 hasConcept C2778720886 @default.
- W2000334785 hasConcept C2781404750 @default.
- W2000334785 hasConcept C42219234 @default.
- W2000334785 hasConcept C71924100 @default.
- W2000334785 hasConcept C83974742 @default.
- W2000334785 hasConceptScore W2000334785C126322002 @default.
- W2000334785 hasConceptScore W2000334785C134018914 @default.
- W2000334785 hasConceptScore W2000334785C15490471 @default.
- W2000334785 hasConceptScore W2000334785C170493617 @default.
- W2000334785 hasConceptScore W2000334785C24998067 @default.
- W2000334785 hasConceptScore W2000334785C2776755955 @default.
- W2000334785 hasConceptScore W2000334785C2778720886 @default.
- W2000334785 hasConceptScore W2000334785C2781404750 @default.
- W2000334785 hasConceptScore W2000334785C42219234 @default.
- W2000334785 hasConceptScore W2000334785C71924100 @default.
- W2000334785 hasConceptScore W2000334785C83974742 @default.
- W2000334785 hasIssue "3" @default.
- W2000334785 hasLocation W20003347851 @default.
- W2000334785 hasLocation W20003347852 @default.
- W2000334785 hasOpenAccess W2000334785 @default.
- W2000334785 hasPrimaryLocation W20003347851 @default.
- W2000334785 hasRelatedWork W1789692432 @default.
- W2000334785 hasRelatedWork W1986799117 @default.
- W2000334785 hasRelatedWork W1998227988 @default.
- W2000334785 hasRelatedWork W2000334785 @default.
- W2000334785 hasRelatedWork W2019049268 @default.
- W2000334785 hasRelatedWork W2064031388 @default.
- W2000334785 hasRelatedWork W2089915552 @default.
- W2000334785 hasRelatedWork W2226562228 @default.
- W2000334785 hasRelatedWork W2316000567 @default.
- W2000334785 hasRelatedWork W2344529250 @default.
- W2000334785 hasVolume "25" @default.
- W2000334785 isParatext "false" @default.
- W2000334785 isRetracted "false" @default.
- W2000334785 magId "2000334785" @default.
- W2000334785 workType "article" @default.