FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000335629> ?p ?o ?g. }

• W2000335629 endingPage "425" @default.
• W2000335629 startingPage "421" @default.
• W2000335629 abstract "Elucidation of the molecular basis of hyper-immunoglobulin-M syndromes has provided considerable insight into the molecular events involved in antibody maturation, including immunoglobulin class switch recombination and the generation of somatic hypermutation.The identification of activation-induced cytidine deaminase deficiency (hyper-immunoglobulin-M syndrome 2) has revealed the key role played by this inducible B cell-specific molecule in both class switch recombination and somatic hypermutation. Data from Escherichia coli and in-vitro assays have strongly suggested that activation-induced cytidine deaminase acts as a DNA-editing enzyme in these processes. The recent description of a new hyper-immunoglobulin-M syndrome caused by mutations in the gene encoding the uracil-N glycosylase provided further evidence that activation-induced cytidine deaminase acts on deoxycytidine in the switch and variable regions. Indeed, uracil-N glycosylase is required to remove the uracil residues integrated into DNA following deoxycytidine deamination by activation-induced cytidine deaminase. Another hyper-immunoglobulin-M condition has recently been described (hyper-immunoglobulin-M syndrome 4). Its molecular basis is unknown, but it appears to be a homogeneous entity characterized by an intrinsic B cell defective class switch recombination but normal generation of somatic hypermutation. It is probably caused by a class switch recombination-specific DNA repair defect because class switch recombination-induced DNA breaks in S regions are normally detected in patients with this condition.The heterogeneity in hyper-immunoglobulin-M syndromes will continue to shed light on the molecular mechanisms of class switch recombination and somatic hypermutation. The description of hyper-immunoglobulin-M syndromes may therefore lead to improvements in the care of these patients." @default.
• W2000335629 created "2016-06-24" @default.
• W2000335629 creator A5025155115 @default.
• W2000335629 creator A5029004287 @default.
• W2000335629 creator A5031904282 @default.
• W2000335629 date "2003-12-01" @default.
• W2000335629 modified "2023-10-17" @default.
• W2000335629 title "Hyper-immunoglobulin-M syndromes caused by an intrinsic B cell defect" @default.
• W2000335629 cites W1966075431 @default.
• W2000335629 cites W1966200086 @default.
• W2000335629 cites W1968950713 @default.
• W2000335629 cites W1970966311 @default.
• W2000335629 cites W1980632664 @default.
• W2000335629 cites W1980898330 @default.
• W2000335629 cites W1999207703 @default.
• W2000335629 cites W2002043709 @default.
• W2000335629 cites W2008489452 @default.
• W2000335629 cites W2008527950 @default.
• W2000335629 cites W2012648382 @default.
• W2000335629 cites W2021034954 @default.
• W2000335629 cites W2024303560 @default.
• W2000335629 cites W2029864255 @default.
• W2000335629 cites W2031778684 @default.
• W2000335629 cites W2036806870 @default.
• W2000335629 cites W2045816796 @default.
• W2000335629 cites W2048066082 @default.
• W2000335629 cites W2058061737 @default.
• W2000335629 cites W2060019843 @default.
• W2000335629 cites W2062738638 @default.
• W2000335629 cites W2073622904 @default.
• W2000335629 cites W2074713423 @default.
• W2000335629 cites W2080292702 @default.
• W2000335629 cites W2080795138 @default.
• W2000335629 cites W2091413140 @default.
• W2000335629 cites W2100736164 @default.
• W2000335629 cites W2106336456 @default.
• W2000335629 cites W2107408311 @default.
• W2000335629 cites W2112640636 @default.
• W2000335629 cites W2114604974 @default.
• W2000335629 cites W2114983967 @default.
• W2000335629 cites W2116025169 @default.
• W2000335629 cites W2117421686 @default.
• W2000335629 cites W2130651020 @default.
• W2000335629 cites W2132767317 @default.
• W2000335629 cites W2136960636 @default.
• W2000335629 cites W2136978195 @default.
• W2000335629 cites W2138938081 @default.
• W2000335629 cites W2139387072 @default.
• W2000335629 cites W2141326900 @default.
• W2000335629 cites W2146532448 @default.
• W2000335629 cites W2150010396 @default.
• W2000335629 cites W2165608602 @default.
• W2000335629 doi "https://doi.org/10.1097/00130832-200312000-00002" @default.
• W2000335629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14612665" @default.
• W2000335629 hasPublicationYear "2003" @default.
• W2000335629 type Work @default.
• W2000335629 sameAs 2000335629 @default.
• W2000335629 citedByCount "15" @default.
• W2000335629 countsByYear W20003356292012 @default.
• W2000335629 countsByYear W20003356292013 @default.
• W2000335629 countsByYear W20003356292014 @default.
• W2000335629 countsByYear W20003356292017 @default.
• W2000335629 countsByYear W20003356292019 @default.
• W2000335629 crossrefType "journal-article" @default.
• W2000335629 hasAuthorship W2000335629A5025155115 @default.
• W2000335629 hasAuthorship W2000335629A5029004287 @default.
• W2000335629 hasAuthorship W2000335629A5031904282 @default.
• W2000335629 hasConcept C128526571 @default.
• W2000335629 hasConcept C137756551 @default.
• W2000335629 hasConcept C153911025 @default.
• W2000335629 hasConcept C159654299 @default.
• W2000335629 hasConcept C181199279 @default.
• W2000335629 hasConcept C27082348 @default.
• W2000335629 hasConcept C2776985229 @default.
• W2000335629 hasConcept C2778453870 @default.
• W2000335629 hasConcept C2781184954 @default.
• W2000335629 hasConcept C3020196193 @default.
• W2000335629 hasConcept C54355233 @default.
• W2000335629 hasConcept C55493867 @default.
• W2000335629 hasConcept C86803240 @default.
• W2000335629 hasConceptScore W2000335629C128526571 @default.
• W2000335629 hasConceptScore W2000335629C137756551 @default.
• W2000335629 hasConceptScore W2000335629C153911025 @default.
• W2000335629 hasConceptScore W2000335629C159654299 @default.
• W2000335629 hasConceptScore W2000335629C181199279 @default.
• W2000335629 hasConceptScore W2000335629C27082348 @default.
• W2000335629 hasConceptScore W2000335629C2776985229 @default.
• W2000335629 hasConceptScore W2000335629C2778453870 @default.
• W2000335629 hasConceptScore W2000335629C2781184954 @default.
• W2000335629 hasConceptScore W2000335629C3020196193 @default.
• W2000335629 hasConceptScore W2000335629C54355233 @default.
• W2000335629 hasConceptScore W2000335629C55493867 @default.
• W2000335629 hasConceptScore W2000335629C86803240 @default.
• W2000335629 hasIssue "6" @default.
• W2000335629 hasLocation W20003356291 @default.
• W2000335629 hasLocation W20003356292 @default.
• W2000335629 hasOpenAccess W2000335629 @default.
• W2000335629 hasPrimaryLocation W20003356291 @default.

• next