Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000336507> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2000336507 endingPage "869" @default.
- W2000336507 startingPage "865" @default.
- W2000336507 abstract "Summary Inoculation of suckling mice with coxsackievirus B4 (CB4) results in the death of a majority of the animals. In this study we selected antigenic variants of CB4 in the presence of neutralizing monoclonal antibodies and tested them to see whether they were attenuated. Antigenic variants selected with a single antibody showed little or no attenuation by producing a high mortality (60 to 100 %). A double variant selected with two antibodies showed considerable attenuation by causing only 25% mortality. A triple variant selected with three antibodies was almost completely attenuated (killed only 5 % of the animals). Polypeptides from these variants were tested for their ability to interact with the monoclonal antibodies used for their selection. These studies showed that resistance of variant virus to neutralization in general was due to the inability of the antibody to bind to the virus. However, one of the antibodies could bind but not neutralize the virus, perhaps due to an alteration in the epitope. It is concluded that selection of CB4 variants using more than one neutralizing monoclonal antibody can lead to attenuation of the virus." @default.
- W2000336507 created "2016-06-24" @default.
- W2000336507 creator A5004707957 @default.
- W2000336507 creator A5006965309 @default.
- W2000336507 creator A5028650299 @default.
- W2000336507 date "1987-03-01" @default.
- W2000336507 modified "2023-09-26" @default.
- W2000336507 title "Selection of Coxsackievirus B4 Variants with Monoclonal Antibodies Results in Attenuation" @default.
- W2000336507 cites W1520995432 @default.
- W2000336507 cites W160318156 @default.
- W2000336507 cites W1986667365 @default.
- W2000336507 cites W1999393013 @default.
- W2000336507 cites W2001362738 @default.
- W2000336507 cites W2008932944 @default.
- W2000336507 cites W2014318405 @default.
- W2000336507 cites W2018714220 @default.
- W2000336507 cites W2025174118 @default.
- W2000336507 cites W2044967254 @default.
- W2000336507 cites W2045102135 @default.
- W2000336507 cites W2053891047 @default.
- W2000336507 cites W2054149242 @default.
- W2000336507 cites W2054876178 @default.
- W2000336507 cites W2063478723 @default.
- W2000336507 cites W2100837269 @default.
- W2000336507 cites W2101878100 @default.
- W2000336507 cites W2151984697 @default.
- W2000336507 cites W2163171620 @default.
- W2000336507 cites W2235597981 @default.
- W2000336507 doi "https://doi.org/10.1099/0022-1317-68-3-865" @default.
- W2000336507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3029310" @default.
- W2000336507 hasPublicationYear "1987" @default.
- W2000336507 type Work @default.
- W2000336507 sameAs 2000336507 @default.
- W2000336507 citedByCount "14" @default.
- W2000336507 countsByYear W20003365072014 @default.
- W2000336507 crossrefType "journal-article" @default.
- W2000336507 hasAuthorship W2000336507A5004707957 @default.
- W2000336507 hasAuthorship W2000336507A5006965309 @default.
- W2000336507 hasAuthorship W2000336507A5028650299 @default.
- W2000336507 hasBestOaLocation W20003365071 @default.
- W2000336507 hasConcept C14086860 @default.
- W2000336507 hasConcept C147483822 @default.
- W2000336507 hasConcept C159047783 @default.
- W2000336507 hasConcept C159654299 @default.
- W2000336507 hasConcept C195616568 @default.
- W2000336507 hasConcept C203014093 @default.
- W2000336507 hasConcept C2522874641 @default.
- W2000336507 hasConcept C2777888124 @default.
- W2000336507 hasConcept C2779120600 @default.
- W2000336507 hasConcept C542903549 @default.
- W2000336507 hasConcept C86803240 @default.
- W2000336507 hasConceptScore W2000336507C14086860 @default.
- W2000336507 hasConceptScore W2000336507C147483822 @default.
- W2000336507 hasConceptScore W2000336507C159047783 @default.
- W2000336507 hasConceptScore W2000336507C159654299 @default.
- W2000336507 hasConceptScore W2000336507C195616568 @default.
- W2000336507 hasConceptScore W2000336507C203014093 @default.
- W2000336507 hasConceptScore W2000336507C2522874641 @default.
- W2000336507 hasConceptScore W2000336507C2777888124 @default.
- W2000336507 hasConceptScore W2000336507C2779120600 @default.
- W2000336507 hasConceptScore W2000336507C542903549 @default.
- W2000336507 hasConceptScore W2000336507C86803240 @default.
- W2000336507 hasIssue "3" @default.
- W2000336507 hasLocation W20003365071 @default.
- W2000336507 hasLocation W20003365072 @default.
- W2000336507 hasOpenAccess W2000336507 @default.
- W2000336507 hasPrimaryLocation W20003365071 @default.
- W2000336507 hasRelatedWork W1937525010 @default.
- W2000336507 hasRelatedWork W2000336507 @default.
- W2000336507 hasRelatedWork W2006538744 @default.
- W2000336507 hasRelatedWork W2008932944 @default.
- W2000336507 hasRelatedWork W2038043114 @default.
- W2000336507 hasRelatedWork W2060284918 @default.
- W2000336507 hasRelatedWork W2060478755 @default.
- W2000336507 hasRelatedWork W2064399553 @default.
- W2000336507 hasRelatedWork W2101878100 @default.
- W2000336507 hasRelatedWork W2916783294 @default.
- W2000336507 hasVolume "68" @default.
- W2000336507 isParatext "false" @default.
- W2000336507 isRetracted "false" @default.
- W2000336507 magId "2000336507" @default.
- W2000336507 workType "article" @default.