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- W2000337130 abstract "The objective of this study was to compare the frequency of two common p21WAF1/Cip1 gene polymorphisms in ovarian cancer patients with that in age-matched controls, from a population originating from Eastern Scotland. Both polymorphisms were found significantly less frequently in both the constitutive and tumour tissue DNA of ovarian cancer patients (3/65; 4.6%), than in that from geographically and age-matched controls (25/186; 13.4%) (p=0.0495, chi2). Furthermore, we found no p21WAF1/Cip1 gene mutations in any of the tumours, reflected by a relatively low degree of loss of heterozygosity (LOH) at the chromosomal region where the gene maps, providing further evidence that the p21WAF1/Cip1 gene is not mutated in ovarian cancer. The data suggest however, that there may potentially be a protective function for the two p21WAF1/Cip1 gene polymorphisms in the population under study." @default.
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- W2000337130 date "1999-07-01" @default.
- W2000337130 modified "2023-09-26" @default.
- W2000337130 title "A protective role for common p21WAF1/Cip1 polymorphisms in human ovarian cancer." @default.
- W2000337130 doi "https://doi.org/10.3892/ijo.15.1.117" @default.
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