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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000337483> ?p ?o ?g. }

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• W2000337483 abstract "New 2-aminobenzamide-type histone deacetylase (HDAC) inhibitors were synthesized. They feature a sulfur-containing bicyclic arylmethyl moiety-a surface recognition domain introduced to increase in cellular uptake-and a substituted tert-amino group which affects physicochemical properties such as aqueous solubility. Compound 22 with a (2-hydroxyethyl)(4-(thiophen-2-yl)benzyl)amino group reduced the volume of human colon cancer HCT116 xenografts in nude mice to T/C 67% by oral administration at 45mg/kg, which was comparable to the rate (T/C 62%) for a positive control, MS-275. Western blot analyses as well as cell cycle and TUNEL assays by flow cytometry suggested that the two compounds inhibited the growth of cancer cells via similar mechanisms." @default.
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• W2000337483 date "2010-06-01" @default.
• W2000337483 modified "2023-09-24" @default.
• W2000337483 title "New orally bioavailable 2-aminobenzamide-type histone deacetylase inhibitor possessing a (2-hydroxyethyl)(4-(thiophen-2-yl)benzyl)amino group" @default.
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• W2000337483 doi "https://doi.org/10.1016/j.bmc.2010.04.033" @default.
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