FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000338399> ?p ?o ?g. }

• W2000338399 endingPage "1003" @default.
• W2000338399 startingPage "1002" @default.
• W2000338399 abstract "The uptake and metabolism of methionine (Met) are critical for epigenetic regulation, redox homeostasis, and embryo development. Our previous study showed that appropriate supplementation of dietary Met promoted the birth weight and placental angiogenesis of high-prolific sows. To further explore the metabolic effect of Met on pregnant sows, we have evaluated the influence of dietary Met level on Met metabolism, and the relationship between metabolites of Met and reproductive performance, antioxidant ability, and placental angiogenesis throughout the gestation of high-prolific sows. Sixty sows (the 3rd parity, Large White) were randomly divided into 5 groups that were fed diets with standardized ileal digestible (SID) methionine-to-lysine (Met:Lys) ratios of 0.27 (control), 0.32, 0.37, 0.42, and 0.47 from the mating day (gestational d 0, G0d) until the farrowing day. HPLC-MS/MS analysis was used to simultaneously evaluate the metabolites related to Met, e.g. S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH), homocysteine (Hcy), cysteine (Cys), and glutathione (GSH). The concentration of SAM and SAH in plasma had significant fluctuations, especially in late pregnancy. Increasing dietary Met supplementation significantly improved the plasma SAM and methylation potential (SAM-to-SAH ratio) at d 114 of pregnancy (G114d). Moreover, a positive association of the plasma SAM concentration at G114d was observed with the litter weight of born alive (P < 0.05; R2 = 0.58). Furthermore, Hcy concentration in plasma was at the lowest level for 0.37 ratio group at G114d. However, it significantly increased during late pregnancy. Moreover, there were negative correlations between plasma Hcy concentration at G114d (P < 0.05) and the placental vascular density in the fold and stroma (P < 0.05). Compared with the control group, the expression of vascular endothelial growth factor-A (VEGF-A) in the placenta tissue of 0.37 ratio group increased significantly (P < 0.05). Collectively, these findings indicate that dietary Met:Lys ratio (0.37 to 0.57) in the pregnant diet dose not influence the antioxidant ability of the high-prolific sows; however, the improvement of fetal development and placental angiogenesis of high-prolific sows by supplementation of Met are closely associated to the key Met-related metabolite of SAM and Hcy, respectively." @default.
• W2000338399 created "2016-06-24" @default.
• W2000338399 creator A5000043138 @default.
• W2000338399 creator A5037687127 @default.
• W2000338399 creator A5046808655 @default.
• W2000338399 creator A5083838863 @default.
• W2000338399 date "2009-11-01" @default.
• W2000338399 modified "2023-10-05" @default.
• W2000338399 title "Measurement of Housekeeping Genes in Human Placenta" @default.
• W2000338399 cites W1577577364 @default.
• W2000338399 cites W2094358667 @default.
• W2000338399 cites W2131987407 @default.
• W2000338399 cites W2149896049 @default.
• W2000338399 cites W2415493676 @default.
• W2000338399 doi "https://doi.org/10.1016/j.placenta.2009.09.002" @default.
• W2000338399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19819546" @default.
• W2000338399 hasPublicationYear "2009" @default.
• W2000338399 type Work @default.
• W2000338399 sameAs 2000338399 @default.
• W2000338399 citedByCount "44" @default.
• W2000338399 countsByYear W20003383992012 @default.
• W2000338399 countsByYear W20003383992013 @default.
• W2000338399 countsByYear W20003383992014 @default.
• W2000338399 countsByYear W20003383992015 @default.
• W2000338399 countsByYear W20003383992016 @default.
• W2000338399 countsByYear W20003383992017 @default.
• W2000338399 countsByYear W20003383992018 @default.
• W2000338399 countsByYear W20003383992019 @default.
• W2000338399 countsByYear W20003383992020 @default.
• W2000338399 countsByYear W20003383992021 @default.
• W2000338399 countsByYear W20003383992022 @default.
• W2000338399 countsByYear W20003383992023 @default.
• W2000338399 crossrefType "journal-article" @default.
• W2000338399 hasAuthorship W2000338399A5000043138 @default.
• W2000338399 hasAuthorship W2000338399A5037687127 @default.
• W2000338399 hasAuthorship W2000338399A5046808655 @default.
• W2000338399 hasAuthorship W2000338399A5083838863 @default.
• W2000338399 hasConcept C112672928 @default.
• W2000338399 hasConcept C126322002 @default.
• W2000338399 hasConcept C134018914 @default.
• W2000338399 hasConcept C16525657 @default.
• W2000338399 hasConcept C16685009 @default.
• W2000338399 hasConcept C172680121 @default.
• W2000338399 hasConcept C181199279 @default.
• W2000338399 hasConcept C196843134 @default.
• W2000338399 hasConcept C2776953305 @default.
• W2000338399 hasConcept C2777090595 @default.
• W2000338399 hasConcept C2779234561 @default.
• W2000338399 hasConcept C2779429622 @default.
• W2000338399 hasConcept C2780912031 @default.
• W2000338399 hasConcept C46973012 @default.
• W2000338399 hasConcept C515207424 @default.
• W2000338399 hasConcept C538909803 @default.
• W2000338399 hasConcept C54355233 @default.
• W2000338399 hasConcept C55493867 @default.
• W2000338399 hasConcept C6557445 @default.
• W2000338399 hasConcept C66322754 @default.
• W2000338399 hasConcept C71924100 @default.
• W2000338399 hasConcept C86803240 @default.
• W2000338399 hasConceptScore W2000338399C112672928 @default.
• W2000338399 hasConceptScore W2000338399C126322002 @default.
• W2000338399 hasConceptScore W2000338399C134018914 @default.
• W2000338399 hasConceptScore W2000338399C16525657 @default.
• W2000338399 hasConceptScore W2000338399C16685009 @default.
• W2000338399 hasConceptScore W2000338399C172680121 @default.
• W2000338399 hasConceptScore W2000338399C181199279 @default.
• W2000338399 hasConceptScore W2000338399C196843134 @default.
• W2000338399 hasConceptScore W2000338399C2776953305 @default.
• W2000338399 hasConceptScore W2000338399C2777090595 @default.
• W2000338399 hasConceptScore W2000338399C2779234561 @default.
• W2000338399 hasConceptScore W2000338399C2779429622 @default.
• W2000338399 hasConceptScore W2000338399C2780912031 @default.
• W2000338399 hasConceptScore W2000338399C46973012 @default.
• W2000338399 hasConceptScore W2000338399C515207424 @default.
• W2000338399 hasConceptScore W2000338399C538909803 @default.
• W2000338399 hasConceptScore W2000338399C54355233 @default.
• W2000338399 hasConceptScore W2000338399C55493867 @default.
• W2000338399 hasConceptScore W2000338399C6557445 @default.
• W2000338399 hasConceptScore W2000338399C66322754 @default.
• W2000338399 hasConceptScore W2000338399C71924100 @default.
• W2000338399 hasConceptScore W2000338399C86803240 @default.
• W2000338399 hasIssue "11" @default.
• W2000338399 hasLocation W20003383991 @default.
• W2000338399 hasLocation W20003383992 @default.
• W2000338399 hasOpenAccess W2000338399 @default.
• W2000338399 hasPrimaryLocation W20003383991 @default.
• W2000338399 hasRelatedWork W1977223774 @default.
• W2000338399 hasRelatedWork W1993795923 @default.
• W2000338399 hasRelatedWork W2039466440 @default.
• W2000338399 hasRelatedWork W2073341186 @default.
• W2000338399 hasRelatedWork W2131811784 @default.
• W2000338399 hasRelatedWork W2404549984 @default.
• W2000338399 hasRelatedWork W2415064169 @default.
• W2000338399 hasRelatedWork W2739502069 @default.
• W2000338399 hasRelatedWork W2938106265 @default.
• W2000338399 hasRelatedWork W2991683232 @default.
• W2000338399 hasVolume "30" @default.
• W2000338399 isParatext "false" @default.

• next