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- W2000340234 endingPage "S26" @default.
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- W2000340234 abstract "Blood flow in the optic nerve has been demonstrated to be autoregulated, and, thus, within certain limits, to be independent of the local perfusion pressure. As in the brain, a close coupling of neuronal activity and optic nerve head blood flow has been demonstrated. A number of regulatory systems and factors participate in the regulation of vascular tone in various organs, including the optic nerve. Metabolic and myogenic mechanisms keep local perfusion constant or adapted to the local metabolic needs. Such mechanisms seem to be involved in the regulation of optic nerve blood flow as well. In contrast, neuronal blood flow regulation is of minor importance in the optic nerve. Many of the regulatory modalities induce a response of vascular smooth muscle cells through stimulation of factors produced by the endothelial cell layer. Indeed, endothelial factors are of utmost importance in the regulation of optic nerve blood flow. The facts that there is a basal formation of nitric oxide, which leads to an active dilation of the ocular vasculature, and that endothelin-1 decreases blood flow to the anterior optic nerve in a dose-dependent manner suggest that alterations in these regulatory mechanisms might be relevant for optic nerve blood flow alterations as they relate to glaucomatous optic neuropathy. It is hoped that a detailed knowledge of blood flow regulation in the optic nerve might initiate new treatment modalities in optic neuropathies that are hemodynamic and vascular in nature." @default.
- W2000340234 created "2016-06-24" @default.
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- W2000340234 date "1999-06-01" @default.
- W2000340234 modified "2023-10-05" @default.
- W2000340234 title "Physiology of Perfusion as It Relates to the Optic Nerve Head" @default.
- W2000340234 cites W1576560915 @default.
- W2000340234 cites W166643756 @default.
- W2000340234 cites W1821554906 @default.
- W2000340234 cites W1874621311 @default.
- W2000340234 cites W1964194378 @default.
- W2000340234 cites W1964363992 @default.
- W2000340234 cites W1965056745 @default.
- W2000340234 cites W1965130327 @default.
- W2000340234 cites W1965864545 @default.
- W2000340234 cites W1965888576 @default.
- W2000340234 cites W1966078097 @default.
- W2000340234 cites W1968176401 @default.
- W2000340234 cites W1968597772 @default.
- W2000340234 cites W1970024800 @default.
- W2000340234 cites W1971135449 @default.
- W2000340234 cites W1973648197 @default.
- W2000340234 cites W1975567521 @default.
- W2000340234 cites W1980655887 @default.
- W2000340234 cites W1980762198 @default.
- W2000340234 cites W1981643883 @default.
- W2000340234 cites W1985783170 @default.
- W2000340234 cites W1987548612 @default.
- W2000340234 cites W1989399186 @default.
- W2000340234 cites W1995137260 @default.
- W2000340234 cites W1996965420 @default.
- W2000340234 cites W1999629936 @default.
- W2000340234 cites W2001892445 @default.
- W2000340234 cites W2010123281 @default.
- W2000340234 cites W2012847258 @default.
- W2000340234 cites W2013275221 @default.
- W2000340234 cites W2015528315 @default.
- W2000340234 cites W2015996189 @default.
- W2000340234 cites W2017571833 @default.
- W2000340234 cites W2018347317 @default.
- W2000340234 cites W2019758626 @default.
- W2000340234 cites W2025570799 @default.
- W2000340234 cites W2028259815 @default.
- W2000340234 cites W2030387465 @default.
- W2000340234 cites W2032643647 @default.
- W2000340234 cites W2037867131 @default.
- W2000340234 cites W2039565245 @default.
- W2000340234 cites W2042889893 @default.
- W2000340234 cites W2042963094 @default.
- W2000340234 cites W2044091567 @default.
- W2000340234 cites W2046548142 @default.
- W2000340234 cites W2047496403 @default.
- W2000340234 cites W2047656366 @default.
- W2000340234 cites W2049695644 @default.
- W2000340234 cites W2050359518 @default.
- W2000340234 cites W2052706062 @default.
- W2000340234 cites W2056261029 @default.
- W2000340234 cites W2059925177 @default.
- W2000340234 cites W2060117625 @default.
- W2000340234 cites W2062327559 @default.
- W2000340234 cites W2064638499 @default.
- W2000340234 cites W2069090309 @default.
- W2000340234 cites W2070539199 @default.
- W2000340234 cites W2072881238 @default.
- W2000340234 cites W2075421062 @default.
- W2000340234 cites W2078941115 @default.
- W2000340234 cites W2079063592 @default.
- W2000340234 cites W2079822082 @default.
- W2000340234 cites W2080268297 @default.
- W2000340234 cites W2080968716 @default.
- W2000340234 cites W2082502803 @default.
- W2000340234 cites W2087066207 @default.
- W2000340234 cites W2092620816 @default.
- W2000340234 cites W2105064809 @default.
- W2000340234 cites W2118471878 @default.
- W2000340234 cites W2119396182 @default.
- W2000340234 cites W2119595385 @default.
- W2000340234 cites W2126016623 @default.
- W2000340234 cites W2127179915 @default.
- W2000340234 cites W2139528085 @default.
- W2000340234 cites W2152359303 @default.
- W2000340234 cites W2160772377 @default.
- W2000340234 cites W2161818634 @default.
- W2000340234 cites W2170515927 @default.
- W2000340234 cites W2201476461 @default.
- W2000340234 cites W2341398312 @default.
- W2000340234 doi "https://doi.org/10.1016/s0039-6257(99)00009-0" @default.
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