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- W2000340528 abstract "<i>Background:</i> Genetic processes underlying fetal lung development and maturation are incompletely understood. Better knowledge of these processes would provide insights into the causes of lung malformations and prevention of respiratory distress syndrome and the potential adverse effects of glucocorticoids. <i>Hox</i> genes are involved in the lung branching morphogenesis and maturation of respiratory epithelium, but their expression pattern remains to be defined. <i>Objectives:</i> We hypothesized that genes involved in lung branching would be downregulated during early development, whereas those involved in maturation would be unchanged or upregulated. <i>Methods:</i> TaqMan real-time primers and probes were designed for all 39 murine <i>Hox</i> genes, and the murine <i>SP-B</i> gene and transcription profiles of these genes were obtained from whole lungs isolated at e14.5, e16.5, e18.5, e19.5 and postnatal days 1 and 20. <i>Results:</i><i>Hox</i> genes in clusters A and B, specifically those between paralog groups 3 and 7, were the most represented, with <i>Hoxa4</i> and <i>Hoxa5</i> being the most highly transcribed. A wave of reduced transcription in 16 <i>Hox</i> genes, coincident with increased <i>SP-B</i> transcription, was observed with advancing gestation. Consistently high transcription of <i>Hoxa5</i> from e14.5 to postnatal day 20 may indicate that sustained transcription is required for normal lung maturation. When e15.5 lungs were cultured with dexamethasone, <i>Hoxb6</i>, <i>Hoxb7</i> and <i>Hoxb8</i> levels were significantly upregulated, creating the potential for modulation of diverse downstream target genes. <i>Conclusions:</i> Improved understanding of the genetic processes underlying lung development afforded by our Q-PCR platform may allow development of more specific methods for inducing fetal lung maturation." @default.
- W2000340528 created "2016-06-24" @default.
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- W2000340528 date "2009-01-01" @default.
- W2000340528 modified "2023-09-26" @default.
- W2000340528 title "Quantification of <i>Hox</i> and <i>Surfactant Protein-B</i> Transcription during Murine Lung Development" @default.
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- W2000340528 doi "https://doi.org/10.1159/000201739" @default.
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