Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000340734> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2000340734 endingPage "294" @default.
- W2000340734 startingPage "294" @default.
- W2000340734 abstract "The aporphine alkaloids boldine and glaucine have been reported to show “neuroleptic-like” actions in mice, suggesting that they may act as dopamine antagonists. We have found that in vitro boldine displaces specific striatal [3H]-SCH 23390 binding with IC50 = 0.4 μM and [3H]-raclopride binding with IC50 = 0.5 μM, while the affinities of glaucine at the same sites are an order of magnitude lower. In vivo, however, 40 mg/kg boldine (IP) did not modify specific striatal [3H]-raclopride binding and only decreased [3H]-SCH 23390 binding by 25%. On the other hand, 40 mg/kg glaucine (IP) displaced both radioligands by about 50%. Behaviors (climbing, sniffing, grooming) elicited in mice by apomorphine (0.75 mg/kg SC) were not modified by boldine at doses up to 40 mg/kg (IP) but were almost completely abolished by 40 mg/kg glaucine (IP). In the apomorphine-induced (0.1 mg/kg SC) rat yawning and penile erection model, boldine and glaucine appeared to be similarly effective, inhibiting both behaviors by more than 50% at 40 mg/kg (IP). Boldine and glaucine, injected IP at doses up to 40 mg/kg, were poor modifiers of dopamine metabolism in mouse and rat striatum. These data suggest that boldine does not display effective central dopaminergic antagonist activities in vivo in spite of its good binding affinity at D1- and D2-like receptors, and that glaucine, although less effective in vitro, does appear to exhibit some antidopaminergic properties in vivo." @default.
- W2000340734 created "2016-06-24" @default.
- W2000340734 creator A5024597181 @default.
- W2000340734 creator A5032905339 @default.
- W2000340734 creator A5085404403 @default.
- W2000340734 date "1991-05-01" @default.
- W2000340734 modified "2023-10-18" @default.
- W2000340734 title "Association of pineal gland calcification with neuroleptic dose in chronic schizophrenia" @default.
- W2000340734 doi "https://doi.org/10.1016/0920-9964(91)90173-o" @default.
- W2000340734 hasPublicationYear "1991" @default.
- W2000340734 type Work @default.
- W2000340734 sameAs 2000340734 @default.
- W2000340734 citedByCount "0" @default.
- W2000340734 crossrefType "journal-article" @default.
- W2000340734 hasAuthorship W2000340734A5024597181 @default.
- W2000340734 hasAuthorship W2000340734A5032905339 @default.
- W2000340734 hasAuthorship W2000340734A5085404403 @default.
- W2000340734 hasConcept C126322002 @default.
- W2000340734 hasConcept C134018914 @default.
- W2000340734 hasConcept C137183658 @default.
- W2000340734 hasConcept C150903083 @default.
- W2000340734 hasConcept C170493617 @default.
- W2000340734 hasConcept C185592680 @default.
- W2000340734 hasConcept C207001950 @default.
- W2000340734 hasConcept C2776885963 @default.
- W2000340734 hasConcept C2777525119 @default.
- W2000340734 hasConcept C2779917531 @default.
- W2000340734 hasConcept C2780062018 @default.
- W2000340734 hasConcept C2781069445 @default.
- W2000340734 hasConcept C513476851 @default.
- W2000340734 hasConcept C55493867 @default.
- W2000340734 hasConcept C71924100 @default.
- W2000340734 hasConcept C86803240 @default.
- W2000340734 hasConcept C98274493 @default.
- W2000340734 hasConceptScore W2000340734C126322002 @default.
- W2000340734 hasConceptScore W2000340734C134018914 @default.
- W2000340734 hasConceptScore W2000340734C137183658 @default.
- W2000340734 hasConceptScore W2000340734C150903083 @default.
- W2000340734 hasConceptScore W2000340734C170493617 @default.
- W2000340734 hasConceptScore W2000340734C185592680 @default.
- W2000340734 hasConceptScore W2000340734C207001950 @default.
- W2000340734 hasConceptScore W2000340734C2776885963 @default.
- W2000340734 hasConceptScore W2000340734C2777525119 @default.
- W2000340734 hasConceptScore W2000340734C2779917531 @default.
- W2000340734 hasConceptScore W2000340734C2780062018 @default.
- W2000340734 hasConceptScore W2000340734C2781069445 @default.
- W2000340734 hasConceptScore W2000340734C513476851 @default.
- W2000340734 hasConceptScore W2000340734C55493867 @default.
- W2000340734 hasConceptScore W2000340734C71924100 @default.
- W2000340734 hasConceptScore W2000340734C86803240 @default.
- W2000340734 hasConceptScore W2000340734C98274493 @default.
- W2000340734 hasIssue "3" @default.
- W2000340734 hasLocation W20003407341 @default.
- W2000340734 hasOpenAccess W2000340734 @default.
- W2000340734 hasPrimaryLocation W20003407341 @default.
- W2000340734 hasRelatedWork W1990802458 @default.
- W2000340734 hasRelatedWork W2008561016 @default.
- W2000340734 hasRelatedWork W2019559847 @default.
- W2000340734 hasRelatedWork W2064701773 @default.
- W2000340734 hasRelatedWork W2070732599 @default.
- W2000340734 hasRelatedWork W2072433126 @default.
- W2000340734 hasRelatedWork W2077353011 @default.
- W2000340734 hasRelatedWork W2110771878 @default.
- W2000340734 hasRelatedWork W2150568116 @default.
- W2000340734 hasRelatedWork W3146301921 @default.
- W2000340734 hasVolume "4" @default.
- W2000340734 isParatext "false" @default.
- W2000340734 isRetracted "false" @default.
- W2000340734 magId "2000340734" @default.
- W2000340734 workType "article" @default.