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- W2000340986 abstract "The wild-type trp repressor of E. coli bound 5-methoxytryptophan, a Trp analogue, less tightly than Trp. A mutant repressor (Val58→Ala) that should bind 5-methoxytryptophan preferentially to Trp was computationally designed by free-energy calculations accompanied by free-energy decomposition. The designed mutant was demonstrated by experiments to bind 5-methoxytryptophan more tightly than Trp, consistent with the computational prediction. This success indicates the usefulness of free energy decomposition in protein design. Proteins 26:459–464 © 1996 Wiley-Liss, Inc." @default.
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- W2000340986 title "Computational design of a substrate specificity mutant of a protein" @default.
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- W2000340986 doi "https://doi.org/10.1002/(sici)1097-0134(199612)26:4<459::aid-prot6>3.0.co;2-6" @default.
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