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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000341184> ?p ?o ?g. }

• W2000341184 endingPage "1477" @default.
• W2000341184 startingPage "1470" @default.
• W2000341184 abstract "The role of neuronally derived nitric oxide (NO) in neurotransmission and neural injury remains an area of active investigation. NO generation has been postulated to be involved in the deleterious events surrounding ischemia/reperfusion injury either directly or via the production of more reactive oxidants such as peroxynitrite. In our search for novel therapeutics for the treatment of a variety of neurological diseases including stroke, we have discovered novel, potent, and selective inhibitors of the neuronal nitric oxide synthase (nNOS) isoform. These compounds have proven to be effective in models of ischemia/reperfusion supporting the role of nNOS in these processes. The effects of these compounds as well as additional aspects critical to their development will be presented." @default.
• W2000341184 created "2016-06-24" @default.
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• W2000341184 date "2000-05-01" @default.
• W2000341184 modified "2023-10-16" @default.
• W2000341184 title "Discovery and development of neuronal nitric oxide synthase inhibitors" @default.
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• W2000341184 doi "https://doi.org/10.1016/s0891-5849(00)00250-1" @default.
• W2000341184 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10927171" @default.
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