Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000341871> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2000341871 endingPage "219" @default.
- W2000341871 startingPage "205" @default.
- W2000341871 abstract "The effects of continuous exposure to ethanol on the cytological and physiological development of a central nervous system (CNS) neuron were studied using the cultured Purkinje neuron of the rat cerebellar cortex. Purkinje neurons in fetal rat brain cultures which are established at one day before birth show development comparable to that described in vivo in other studies. In culture, Purkinje neurons progress from immature rounded cells with fine neurites to mature neurons with a branched dendritic structure. These structural changes are accompanied by an increase in the duration and complexity of the excitatory response to glutamate, by transitions in the patterns of spontaneous activity, and by an increase in mean firing rate. Our results demonstrate that chronic exposure to a low concentration of ethanol (90 mg%; 19.5 mM) during development selectively alters the electrophysiological but not the morphological properties of Purkinje neurons. Specifically, ethanol treatment reduces the responsiveness of these neurons to glutamate, delays the expected developmental transitions in patterns of spontaneous activity, and induces increased spontaneous bursting activity, particularly at the stage of dendritic formation. Impairment of responsiveness to glutamate is significant in that it may reflect the compromise by ethanol of a major excitatory pathway in the cerebellar cortex, resulting from the decreased efficacy of glutamatergic input from parallel fibers. In contrast to the results of other studies using adult neurons as a model for the effects of ethanol, our work suggests that the developing CNS neuron does not become tolerant; that is, in the continuing presence of ethanol, it does not express physiological function equivalent to that of the control." @default.
- W2000341871 created "2016-06-24" @default.
- W2000341871 creator A5018318289 @default.
- W2000341871 creator A5058099278 @default.
- W2000341871 date "1987-09-01" @default.
- W2000341871 modified "2023-09-23" @default.
- W2000341871 title "Development of spontaneous and glutamate-evoked activity is altered by chronic ethanol in cultured cerebellar Purkinje neurons" @default.
- W2000341871 cites W1992758540 @default.
- W2000341871 cites W1995914346 @default.
- W2000341871 cites W1996030000 @default.
- W2000341871 cites W2000016530 @default.
- W2000341871 cites W2000923894 @default.
- W2000341871 cites W2030380478 @default.
- W2000341871 cites W2031770318 @default.
- W2000341871 cites W2033452181 @default.
- W2000341871 cites W2038963734 @default.
- W2000341871 cites W2041788158 @default.
- W2000341871 cites W2053703922 @default.
- W2000341871 cites W2055681338 @default.
- W2000341871 cites W2059371894 @default.
- W2000341871 cites W2062915733 @default.
- W2000341871 cites W2069099013 @default.
- W2000341871 cites W2070189357 @default.
- W2000341871 cites W2072808724 @default.
- W2000341871 cites W2078877036 @default.
- W2000341871 cites W2092833812 @default.
- W2000341871 cites W2104321133 @default.
- W2000341871 cites W2137462759 @default.
- W2000341871 cites W2154933824 @default.
- W2000341871 cites W2294386995 @default.
- W2000341871 cites W2913477052 @default.
- W2000341871 cites W4214868137 @default.
- W2000341871 doi "https://doi.org/10.1016/0006-8993(87)91240-6" @default.
- W2000341871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2890413" @default.
- W2000341871 hasPublicationYear "1987" @default.
- W2000341871 type Work @default.
- W2000341871 sameAs 2000341871 @default.
- W2000341871 citedByCount "28" @default.
- W2000341871 countsByYear W20003418712015 @default.
- W2000341871 countsByYear W20003418712019 @default.
- W2000341871 crossrefType "journal-article" @default.
- W2000341871 hasAuthorship W2000341871A5018318289 @default.
- W2000341871 hasAuthorship W2000341871A5058099278 @default.
- W2000341871 hasConcept C112592302 @default.
- W2000341871 hasConcept C169760540 @default.
- W2000341871 hasConcept C170493617 @default.
- W2000341871 hasConcept C17077164 @default.
- W2000341871 hasConcept C185263204 @default.
- W2000341871 hasConcept C185592680 @default.
- W2000341871 hasConcept C195221683 @default.
- W2000341871 hasConcept C2778794669 @default.
- W2000341871 hasConcept C2779652256 @default.
- W2000341871 hasConcept C2780648746 @default.
- W2000341871 hasConcept C2992333117 @default.
- W2000341871 hasConcept C529278444 @default.
- W2000341871 hasConcept C55493867 @default.
- W2000341871 hasConcept C61174792 @default.
- W2000341871 hasConcept C86803240 @default.
- W2000341871 hasConceptScore W2000341871C112592302 @default.
- W2000341871 hasConceptScore W2000341871C169760540 @default.
- W2000341871 hasConceptScore W2000341871C170493617 @default.
- W2000341871 hasConceptScore W2000341871C17077164 @default.
- W2000341871 hasConceptScore W2000341871C185263204 @default.
- W2000341871 hasConceptScore W2000341871C185592680 @default.
- W2000341871 hasConceptScore W2000341871C195221683 @default.
- W2000341871 hasConceptScore W2000341871C2778794669 @default.
- W2000341871 hasConceptScore W2000341871C2779652256 @default.
- W2000341871 hasConceptScore W2000341871C2780648746 @default.
- W2000341871 hasConceptScore W2000341871C2992333117 @default.
- W2000341871 hasConceptScore W2000341871C529278444 @default.
- W2000341871 hasConceptScore W2000341871C55493867 @default.
- W2000341871 hasConceptScore W2000341871C61174792 @default.
- W2000341871 hasConceptScore W2000341871C86803240 @default.
- W2000341871 hasIssue "2" @default.
- W2000341871 hasLocation W20003418711 @default.
- W2000341871 hasLocation W20003418712 @default.
- W2000341871 hasOpenAccess W2000341871 @default.
- W2000341871 hasPrimaryLocation W20003418711 @default.
- W2000341871 hasRelatedWork W1992798574 @default.
- W2000341871 hasRelatedWork W2000341871 @default.
- W2000341871 hasRelatedWork W2094353622 @default.
- W2000341871 hasRelatedWork W2100553584 @default.
- W2000341871 hasRelatedWork W2554893316 @default.
- W2000341871 hasRelatedWork W2911853463 @default.
- W2000341871 hasRelatedWork W2982899829 @default.
- W2000341871 hasRelatedWork W2987495083 @default.
- W2000341871 hasRelatedWork W3086570168 @default.
- W2000341871 hasRelatedWork W4328023179 @default.
- W2000341871 hasVolume "420" @default.
- W2000341871 isParatext "false" @default.
- W2000341871 isRetracted "false" @default.
- W2000341871 magId "2000341871" @default.
- W2000341871 workType "article" @default.