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- W2000342281 abstract "Compromised self-awareness of illness-related deficits and behaviors in psychopathology (e.g., schizophrenia) has been associated with deficient functioning of cortical midline regions including the ventromedial prefrontal cortex (vmPFC), implicated in personal relevance. Here, we review and critically analyze recent evidence to suggest that vmPFC abnormalities could similarly underlie deficient tagging of personal relevance in drug addiction, evidenced by a constellation of behaviors encompassing drug-biased attention, negative outcome insensitivity, self-report/behavior dissociation, and social inappropriateness. This novel framework might clarify, for example, why drug-addicted individuals often ruin long-standing relationships or forego important job opportunities while continuing to engage in uncontrolled drug-taking. Therapeutic interventions targeting personal relevance and associated vmPFC functioning could enhance self-awareness and facilitate more adaptive behavior in this chronically relapsing psychopathology." @default.
- W2000342281 created "2016-06-24" @default.
- W2000342281 creator A5066625393 @default.
- W2000342281 creator A5091523623 @default.
- W2000342281 date "2014-12-01" @default.
- W2000342281 modified "2023-10-01" @default.
- W2000342281 title "Impaired self-awareness in human addiction: deficient attribution of personal relevance" @default.
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- W2000342281 doi "https://doi.org/10.1016/j.tics.2014.09.003" @default.
- W2000342281 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4254155" @default.
- W2000342281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25278368" @default.
- W2000342281 hasPublicationYear "2014" @default.
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