FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000342972> ?p ?o ?g. }

• W2000342972 endingPage "847" @default.
• W2000342972 startingPage "847" @default.
• W2000342972 abstract "Objective: To evaluate whether a brief course of treatment with gallium nitrate can reduce biochemical parameters of accelerated bone turnover in patients with advanced Paget disease. Design: Unblinded trial, decreasing dose schedules of gallium nitrate. Setting: University hospital with primary orthopedic and metabolic bone disease specialty. Patients: Ten patients with advanced Paget disease who had previously received conventional therapy consisting of calcitonin, etidronate, or mithramycin. Interventions: Five patients were entered into each of three dose schedules: 2. 5 mg/kg body weight per day by continuous intravenous infusion for 7 days; 0.5 mg/kg per day for 14 days by subcutaneous injection; and 0.25 mg/kg per day for 14 days by subcutaneous injection. Several patients were treated with different dose schedules. Patients were followed until relapse. Results: Fifteen courses of treatment were administered to ten patients. Reductions in serum alkaline phosphatase and urinary hydroxyproline excretion were observed after treatment with each dose schedule. After treatment with high, intermediate, and low doses, the median maximum decreases in serum alkaline phosphatase activity were 49%, 39%, and 18%, respectively. The median maximum decreases in urinary hydroxyproline excretion were 50%, 52%, and 16%, respectively. The maximum decrease in urinary hydroxyproline excretion occurred within a median of 2 weeks from the start of treatment, whereas the maximum decrease in serum alkaline phosphatase activity occurred substantially later at a median of 6 weeks. All treatment schedules were well tolerated. Response duration was highly variable (range, 6 to 42 weeks). Conclusions: Short-term treatment with gallium nitrate can reduce biochemical parameters of disease activity in patients with advanced Paget disease of bone. Larger trials using low-dose intermittent treatment schedules are required to evaluate the safety and effectiveness of this therapy." @default.
• W2000342972 created "2016-06-24" @default.
• W2000342972 creator A5005476187 @default.
• W2000342972 creator A5021115355 @default.
• W2000342972 creator A5024451211 @default.
• W2000342972 creator A5049899013 @default.
• W2000342972 creator A5063108298 @default.
• W2000342972 creator A5081680896 @default.
• W2000342972 date "1990-12-01" @default.
• W2000342972 modified "2023-09-27" @default.
• W2000342972 title "Gallium Nitrate for Advanced Paget Disease of Bone: Effectiveness and Dose-Response Analysis" @default.
• W2000342972 cites W1531901232 @default.
• W2000342972 cites W1549314796 @default.
• W2000342972 cites W1780644854 @default.
• W2000342972 cites W1831379215 @default.
• W2000342972 cites W1920907667 @default.
• W2000342972 cites W1975492526 @default.
• W2000342972 cites W1979697119 @default.
• W2000342972 cites W1981715502 @default.
• W2000342972 cites W1992884108 @default.
• W2000342972 cites W1993111455 @default.
• W2000342972 cites W2002848769 @default.
• W2000342972 cites W2008196272 @default.
• W2000342972 cites W2026256336 @default.
• W2000342972 cites W2037935981 @default.
• W2000342972 cites W2050980203 @default.
• W2000342972 cites W2054881189 @default.
• W2000342972 cites W2060313479 @default.
• W2000342972 cites W2066849271 @default.
• W2000342972 cites W2073998611 @default.
• W2000342972 cites W2080135613 @default.
• W2000342972 cites W2080270454 @default.
• W2000342972 cites W2085234200 @default.
• W2000342972 cites W2095985832 @default.
• W2000342972 cites W2102263650 @default.
• W2000342972 cites W2106142458 @default.
• W2000342972 cites W2120078554 @default.
• W2000342972 cites W2129223584 @default.
• W2000342972 cites W2131647608 @default.
• W2000342972 doi "https://doi.org/10.7326/0003-4819-113-11-847" @default.
• W2000342972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2240900" @default.
• W2000342972 hasPublicationYear "1990" @default.
• W2000342972 type Work @default.
• W2000342972 sameAs 2000342972 @default.
• W2000342972 citedByCount "52" @default.
• W2000342972 countsByYear W20003429722012 @default.
• W2000342972 countsByYear W20003429722013 @default.
• W2000342972 countsByYear W20003429722015 @default.
• W2000342972 countsByYear W20003429722017 @default.
• W2000342972 countsByYear W20003429722020 @default.
• W2000342972 countsByYear W20003429722021 @default.
• W2000342972 countsByYear W20003429722022 @default.
• W2000342972 countsByYear W20003429722023 @default.
• W2000342972 crossrefType "journal-article" @default.
• W2000342972 hasAuthorship W2000342972A5005476187 @default.
• W2000342972 hasAuthorship W2000342972A5021115355 @default.
• W2000342972 hasAuthorship W2000342972A5024451211 @default.
• W2000342972 hasAuthorship W2000342972A5049899013 @default.
• W2000342972 hasAuthorship W2000342972A5063108298 @default.
• W2000342972 hasAuthorship W2000342972A5081680896 @default.
• W2000342972 hasConcept C10146269 @default.
• W2000342972 hasConcept C126322002 @default.
• W2000342972 hasConcept C126894567 @default.
• W2000342972 hasConcept C141071460 @default.
• W2000342972 hasConcept C160160445 @default.
• W2000342972 hasConcept C181199279 @default.
• W2000342972 hasConcept C185592680 @default.
• W2000342972 hasConcept C2779797417 @default.
• W2000342972 hasConcept C55493867 @default.
• W2000342972 hasConcept C71924100 @default.
• W2000342972 hasConcept C90924648 @default.
• W2000342972 hasConceptScore W2000342972C10146269 @default.
• W2000342972 hasConceptScore W2000342972C126322002 @default.
• W2000342972 hasConceptScore W2000342972C126894567 @default.
• W2000342972 hasConceptScore W2000342972C141071460 @default.
• W2000342972 hasConceptScore W2000342972C160160445 @default.
• W2000342972 hasConceptScore W2000342972C181199279 @default.
• W2000342972 hasConceptScore W2000342972C185592680 @default.
• W2000342972 hasConceptScore W2000342972C2779797417 @default.
• W2000342972 hasConceptScore W2000342972C55493867 @default.
• W2000342972 hasConceptScore W2000342972C71924100 @default.
• W2000342972 hasConceptScore W2000342972C90924648 @default.
• W2000342972 hasIssue "11" @default.
• W2000342972 hasLocation W20003429721 @default.
• W2000342972 hasLocation W20003429722 @default.
• W2000342972 hasOpenAccess W2000342972 @default.
• W2000342972 hasPrimaryLocation W20003429721 @default.
• W2000342972 hasRelatedWork W145776775 @default.
• W2000342972 hasRelatedWork W1988320537 @default.
• W2000342972 hasRelatedWork W2002120878 @default.
• W2000342972 hasRelatedWork W2003938723 @default.
• W2000342972 hasRelatedWork W2047967234 @default.
• W2000342972 hasRelatedWork W2118496982 @default.
• W2000342972 hasRelatedWork W2312229954 @default.
• W2000342972 hasRelatedWork W2439875401 @default.
• W2000342972 hasRelatedWork W3025468736 @default.
• W2000342972 hasRelatedWork W2525756941 @default.
• W2000342972 hasVolume "113" @default.

• next