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• W2000345009 abstract "Androgen deprivation therapy (ADT) is a key primary treatment for advanced and metastatic prostate cancer and is an important neoadjuvant before radiotherapy. We evaluated 3.0 T dynamic contrast-enhanced MRI and diffusion-weighted (DW) MRI in monitoring ADT response. Twenty-three consecutive patients with prostate cancer treated by primary ADT were included. Imaging was performed at baseline and 3 months posttreatment with ADT. After 3 months therapy there was a significant reduction in all dynamic contrast-enhanced MRI parameters measured in tumor regions of interest (Ktrans, kep, vp, IAUGC-90); P < 0.001. Areas of normal-appearing peripheral zone showed no significant change; P = 0.285–0.879. Post-ADT, there was no significant change in apparent diffusion coefficient values in tumors, whilst apparent diffusion coefficient values significantly decreased in areas of normal-appearing peripheral zone, from 1.786 × 10−3 mm2/s to 1.561 × 10−3 mm2/s; P = 0.007. As expected the median Prostate-Specific Antigen (PSA) significantly reduced from 30 ng/mL to 1.5 ng/mL posttreatment, and median prostate volume dropped from 47.6 cm3 to 24.9 cm3; P < 0.001. These results suggest that dynamic contrast-enhanced MRI and diffusion-weighted MRI offer different information but that both could prove useful adjuncts to the anatomical information provided by T2-weighted imaging. dynamic contrast-enhanced as a marker of angiogenesis may help demonstrate ADT resistance and diffusion-weighted imaging may be more accurate in determining presence of tumor cell death versus residual tumor. Magn Reson Med, 2012. © 2011 Wiley Periodicals, Inc." @default.
• W2000345009 created "2016-06-24" @default.
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• W2000345009 date "2011-08-29" @default.
• W2000345009 modified "2023-10-12" @default.
• W2000345009 title "DCE and DW MRI in monitoring response to androgen deprivation therapy in patients with prostate cancer: A feasibility study" @default.
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• W2000345009 doi "https://doi.org/10.1002/mrm.23062" @default.
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