FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000345199> ?p ?o ?g. }

• W2000345199 endingPage "877" @default.
• W2000345199 startingPage "867" @default.
• W2000345199 abstract "A high-performance liquid chromatographic (HPLC) assay with native fluorescence detection was developed for the simultaneous quantification of codeine and its two metabolites, morphine and morphine-3-glucuronide (M-3-G), in rat plasma. Solid-phase extraction was used to separate codeine and its metabolites from plasma constituents. Extraction efficiencies of codeine, morphine and M-3-G from rat plasma samples were 97, 92 and 93%, respectively. The chromatographic separation was performed using a reversed-phase C18 column and an elution gradient at ambient temperature. Using native fluorescence detection (excitation at 245 nm and emission at 345 nm), the detection limits of 50 ng/ml for morphine, 25 ng/ml for codeine and 20 ng/ml for M-3-G were obtained. The method had good precision, accuracy and linearity, and was applied to the study of glutethimide's influence on codeine metabolism in rat, following single doses of codeine-glutethimide association. The results confirmed the fact that glutethimide was responsible for a significant increase of morphine plasma levels and for their maintenance in time, concomitant with a significant decrease of M-3-G plasma levels, explained by the inhibition of morphine glucuronidation. In conclusion, glutethimide potentiates and prolongs the analgesic effect of codeine by a pharmacokinetic mechanism." @default.
• W2000345199 created "2016-06-24" @default.
• W2000345199 creator A5038065768 @default.
• W2000345199 creator A5043348875 @default.
• W2000345199 creator A5044995481 @default.
• W2000345199 creator A5051737106 @default.
• W2000345199 date "2003-08-01" @default.
• W2000345199 modified "2023-10-15" @default.
• W2000345199 title "The study of codeine–gluthetimide pharmacokinetic interaction in rats" @default.
• W2000345199 cites W1486823110 @default.
• W2000345199 cites W1932588922 @default.
• W2000345199 cites W1984862370 @default.
• W2000345199 cites W1990118136 @default.
• W2000345199 cites W1994987747 @default.
• W2000345199 cites W1997001068 @default.
• W2000345199 cites W1999241284 @default.
• W2000345199 cites W2013581064 @default.
• W2000345199 cites W2030119548 @default.
• W2000345199 cites W2053041537 @default.
• W2000345199 cites W2057854667 @default.
• W2000345199 cites W2059078389 @default.
• W2000345199 cites W2061384308 @default.
• W2000345199 cites W2062377402 @default.
• W2000345199 cites W2071099120 @default.
• W2000345199 cites W2071616381 @default.
• W2000345199 cites W2086522781 @default.
• W2000345199 cites W2094015302 @default.
• W2000345199 cites W2111125524 @default.
• W2000345199 cites W2117418303 @default.
• W2000345199 cites W2121105864 @default.
• W2000345199 cites W2137127797 @default.
• W2000345199 cites W2145070273 @default.
• W2000345199 cites W75983937 @default.
• W2000345199 doi "https://doi.org/10.1016/s0731-7085(03)00189-4" @default.
• W2000345199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12899973" @default.
• W2000345199 hasPublicationYear "2003" @default.
• W2000345199 type Work @default.
• W2000345199 sameAs 2000345199 @default.
• W2000345199 citedByCount "15" @default.
• W2000345199 countsByYear W20003451992012 @default.
• W2000345199 countsByYear W20003451992014 @default.
• W2000345199 countsByYear W20003451992019 @default.
• W2000345199 countsByYear W20003451992021 @default.
• W2000345199 countsByYear W20003451992022 @default.
• W2000345199 countsByYear W20003451992023 @default.
• W2000345199 crossrefType "journal-article" @default.
• W2000345199 hasAuthorship W2000345199A5038065768 @default.
• W2000345199 hasAuthorship W2000345199A5043348875 @default.
• W2000345199 hasAuthorship W2000345199A5044995481 @default.
• W2000345199 hasAuthorship W2000345199A5051737106 @default.
• W2000345199 hasConcept C112705442 @default.
• W2000345199 hasConcept C179998833 @default.
• W2000345199 hasConcept C181199279 @default.
• W2000345199 hasConcept C185592680 @default.
• W2000345199 hasConcept C2777389121 @default.
• W2000345199 hasConcept C2777866328 @default.
• W2000345199 hasConcept C2777889371 @default.
• W2000345199 hasConcept C2779907587 @default.
• W2000345199 hasConcept C43617362 @default.
• W2000345199 hasConcept C4725764 @default.
• W2000345199 hasConcept C55493867 @default.
• W2000345199 hasConcept C71924100 @default.
• W2000345199 hasConcept C81426234 @default.
• W2000345199 hasConcept C87644729 @default.
• W2000345199 hasConcept C98274493 @default.
• W2000345199 hasConceptScore W2000345199C112705442 @default.
• W2000345199 hasConceptScore W2000345199C179998833 @default.
• W2000345199 hasConceptScore W2000345199C181199279 @default.
• W2000345199 hasConceptScore W2000345199C185592680 @default.
• W2000345199 hasConceptScore W2000345199C2777389121 @default.
• W2000345199 hasConceptScore W2000345199C2777866328 @default.
• W2000345199 hasConceptScore W2000345199C2777889371 @default.
• W2000345199 hasConceptScore W2000345199C2779907587 @default.
• W2000345199 hasConceptScore W2000345199C43617362 @default.
• W2000345199 hasConceptScore W2000345199C4725764 @default.
• W2000345199 hasConceptScore W2000345199C55493867 @default.
• W2000345199 hasConceptScore W2000345199C71924100 @default.
• W2000345199 hasConceptScore W2000345199C81426234 @default.
• W2000345199 hasConceptScore W2000345199C87644729 @default.
• W2000345199 hasConceptScore W2000345199C98274493 @default.
• W2000345199 hasIssue "4-5" @default.
• W2000345199 hasLocation W20003451991 @default.
• W2000345199 hasLocation W20003451992 @default.
• W2000345199 hasOpenAccess W2000345199 @default.
• W2000345199 hasPrimaryLocation W20003451991 @default.
• W2000345199 hasRelatedWork W105761671 @default.
• W2000345199 hasRelatedWork W137660362 @default.
• W2000345199 hasRelatedWork W182377040 @default.
• W2000345199 hasRelatedWork W1994603859 @default.
• W2000345199 hasRelatedWork W2017974580 @default.
• W2000345199 hasRelatedWork W2107935602 @default.
• W2000345199 hasRelatedWork W2329625817 @default.
• W2000345199 hasRelatedWork W23342950 @default.
• W2000345199 hasRelatedWork W2413918519 @default.
• W2000345199 hasRelatedWork W2467241518 @default.
• W2000345199 hasVolume "32" @default.
• W2000345199 isParatext "false" @default.
• W2000345199 isRetracted "false" @default.

• next