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- W2000345324 abstract "Neointimal proliferation in response to arterial injury is an important contributor to restenosis. Ionizing radiation inhibits cellular proliferation and may reduce neointimal formation following balloon angioplasty. Using a novel method to deliver a local endovascular radiation dose, we studied the effect of beta irradiation on the intimal proliferative response to placement of titanium stents in porcine iliac arteries. Fourteen titanium stents containing a true beta particle emitting radioisotope, 32 p, were expanded in the iliac arteries of nine NIH miniature swine. Seven control stents, (no 32 p), and seven treatment stents with an activity of 0.14 μCi, were deployed. Treatment effect was assessed by angiography and histomorphologic examination of the stented iliac segments at day 28. The cell proliferation index (%PCNA positive cells/HPF) and cell density (number of cells/HPF) were measured. Stent Type Intimal Area (mm 2 ) Lumen Area (mm 2 ) Percent Area Stenosis Control (n = 7) 2.47 ± 1.00 472 ± 0.67 33.5 ± 9.2% Treatment(n = 7) 1.77 ± 0.44 * 5.38 ± 0.81 * 24.6 ± 4.4% † * p ≤ 0.012 vs. control. † p = 0.0004 vs control Mean neointimal thickness at each wire site for the treatment stents was significantly less than for the control stents, (0.26 ± .05 mm vs, 0.34 ± 0.1 0 mm, p = 0.0037). The mean cell proliferation index (2.15: ± 0.91% vs. 3.95 ± 4.21% p = 0.44) and cell density (362 ± 42 vs. 349 ± 45 p = 0.46) were similar between treatment and control stents. Low dose endovascular irradiation by a beta particle emitting tent reduces neointimal proliferation after experimental stent placement. This novel technique offers potential for the prevention of restenosis." @default.
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- W2000345324 date "1995-02-01" @default.
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- W2000345324 title "773-3 Inhibition of Neointimal Proliferation with a Beta Particle Emitting Stent" @default.
- W2000345324 doi "https://doi.org/10.1016/0735-1097(95)92651-k" @default.
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