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- W2000345718 abstract "Summary: Staphylococcus aureus protein A (SPA) bound to affinity column matrixes has been used for extracorporeal immunoadsorption for the treatment of human autoimmune and neoplastic diseases. SPA is a bacterial immunoglobulin binding factor (IBF) that binds to the Fc region of antibody. The mechanism(s) of action of protein A immunoadsorption is not known. However, protein A immunoadsorption and systemic injection of SPA have demonstrated similar anti-neo6plastic and anti-retroviral responses in animals. Cellular Fc receptor (FcR) immunity and humoral IBF status are often abnormal in autoimmunity, cancer, and AIDS. The immunotherapeutic activity of protein A immunoadsorption may be produced by SPA leaching off columns and acting as a soluble FcR-like IBF, capable of influencing FcR dependent immunity. If this is the case then systemic SPA therapy may provide a simpler, safer, and more predicable mode of immunotherapy than immunoadsorption." @default.
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- W2000345718 date "1997-01-01" @default.
- W2000345718 modified "2023-09-26" @default.
- W2000345718 title "Staphylococcus Aureus Protein A Immunoadsorption: The Rationale for Systemic Protein A Immunotherapy" @default.
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- W2000345718 doi "https://doi.org/10.1080/105172397243277" @default.
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