FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000345968> ?p ?o ?g. }

• W2000345968 endingPage "7" @default.
• W2000345968 startingPage "293" @default.
• W2000345968 abstract "The biological activity of VEGF depends on the presence of its specific receptors on the endothelial surface: VEGFR-1, VEGFR-2, and on their soluble forms sVEGFR-1 and sVEGFR-2. The binding of the membrane-bound receptors with VEGF affects the permeability, proliferation and migration of vascular endothelial cells. This creates the necessary conditions for the vascularisation of solid tumours and for the spread of remote metastases. The sVEGFR-1 and sVEGFR-2 receptors are believed to be natural inhibitors of VEGF.To determine the clinical usefulness of VEGF and the sVEGFR-1 and sVEGFR-2 receptors level assay in women with primary breast cancer. The assessment also took into account: patient's age, stage of the disease, histological grade, status of the axillary lymph nodes and size of the primary tumour.The concentrations of VEGF, sVEGFR-1 and sVEGFR-2 were ascertained in 103 women with primary breast cancer. The concentrations of VEGF in the plasma, and those of the soluble receptors sVEGFR-1 and sVEGFR-2 in the serum, were assessed by ELISA, R&D Systems.The study found significantly raised concentrations of VEGF, sVEGFR-1 and sVEGFR-2 in the serum of women with breast cancer, relative to the values obtained from the control group. It was found that with increasing clinical stages of the disease, the levels of VEGF and concentrations of sVEGFR-1 and sVEGFR-2 also increased. Similar findings were noted when assessing the degree of the histological grade of the tumours. Significantly higher values of VEGF protein and the assessed receptors were obtained from women with metastases to the axillary lymph nodes. A positive relationship, though without statistical significance, was noted between the concentration of sVEGFR-2 and the size of the tumour.The high concentrations of the VEGF cytokine and the sVEGFR-1 and sVEGFR-2 receptors in women with breast cancer are responsible for giving rise to the processes of tumour angiogenesis. The concentrations of the VEGF protein and the soluble forms of the receptors sVEGFR-1 and sVEGFR-2 in the serum of breast cancer patients showed positive correlations with the clinical stage of the disease. These results point to the usefulness of VEGF assessment and its soluble receptors in the clinical evaluation of patients with breast cancer." @default.
• W2000345968 created "2016-06-24" @default.
• W2000345968 creator A5017088825 @default.
• W2000345968 creator A5021081240 @default.
• W2000345968 creator A5069192409 @default.
• W2000345968 creator A5069692774 @default.
• W2000345968 creator A5084535017 @default.
• W2000345968 date "2013-01-01" @default.
• W2000345968 modified "2023-10-17" @default.
• W2000345968 title "Clinical usefulness of assessing VEGF and soluble receptors sVEGFR-1 and sVEGFR-2 in women with breast cancer." @default.
• W2000345968 cites W1572765514 @default.
• W2000345968 cites W1587494584 @default.
• W2000345968 cites W1982246723 @default.
• W2000345968 cites W1986632581 @default.
• W2000345968 cites W2000292756 @default.
• W2000345968 cites W2009968499 @default.
• W2000345968 cites W2018206586 @default.
• W2000345968 cites W2030504942 @default.
• W2000345968 cites W2039307370 @default.
• W2000345968 cites W2043144013 @default.
• W2000345968 cites W2053221827 @default.
• W2000345968 cites W2056408500 @default.
• W2000345968 cites W2067939360 @default.
• W2000345968 cites W2069725398 @default.
• W2000345968 cites W207516804 @default.
• W2000345968 cites W2076733025 @default.
• W2000345968 cites W2092443665 @default.
• W2000345968 cites W2095462135 @default.
• W2000345968 cites W2102140960 @default.
• W2000345968 cites W2112911107 @default.
• W2000345968 cites W2141046053 @default.
• W2000345968 cites W2156094924 @default.
• W2000345968 cites W2166573361 @default.
• W2000345968 cites W2184390138 @default.
• W2000345968 cites W2195147480 @default.
• W2000345968 cites W2227827094 @default.
• W2000345968 cites W2324593222 @default.
• W2000345968 cites W2338661053 @default.
• W2000345968 cites W2384512399 @default.
• W2000345968 cites W3216063631 @default.
• W2000345968 cites W2407662335 @default.
• W2000345968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23772579" @default.
• W2000345968 hasPublicationYear "2013" @default.
• W2000345968 type Work @default.
• W2000345968 sameAs 2000345968 @default.
• W2000345968 citedByCount "12" @default.
• W2000345968 countsByYear W20003459682014 @default.
• W2000345968 countsByYear W20003459682016 @default.
• W2000345968 countsByYear W20003459682017 @default.
• W2000345968 countsByYear W20003459682018 @default.
• W2000345968 countsByYear W20003459682019 @default.
• W2000345968 countsByYear W20003459682023 @default.
• W2000345968 crossrefType "journal-article" @default.
• W2000345968 hasAuthorship W2000345968A5017088825 @default.
• W2000345968 hasAuthorship W2000345968A5021081240 @default.
• W2000345968 hasAuthorship W2000345968A5069192409 @default.
• W2000345968 hasAuthorship W2000345968A5069692774 @default.
• W2000345968 hasAuthorship W2000345968A5084535017 @default.
• W2000345968 hasConcept C121608353 @default.
• W2000345968 hasConcept C126322002 @default.
• W2000345968 hasConcept C134018914 @default.
• W2000345968 hasConcept C143998085 @default.
• W2000345968 hasConcept C146357865 @default.
• W2000345968 hasConcept C151730666 @default.
• W2000345968 hasConcept C167734588 @default.
• W2000345968 hasConcept C170493617 @default.
• W2000345968 hasConcept C2777025900 @default.
• W2000345968 hasConcept C2780394083 @default.
• W2000345968 hasConcept C502942594 @default.
• W2000345968 hasConcept C530470458 @default.
• W2000345968 hasConcept C71924100 @default.
• W2000345968 hasConcept C86803240 @default.
• W2000345968 hasConceptScore W2000345968C121608353 @default.
• W2000345968 hasConceptScore W2000345968C126322002 @default.
• W2000345968 hasConceptScore W2000345968C134018914 @default.
• W2000345968 hasConceptScore W2000345968C143998085 @default.
• W2000345968 hasConceptScore W2000345968C146357865 @default.
• W2000345968 hasConceptScore W2000345968C151730666 @default.
• W2000345968 hasConceptScore W2000345968C167734588 @default.
• W2000345968 hasConceptScore W2000345968C170493617 @default.
• W2000345968 hasConceptScore W2000345968C2777025900 @default.
• W2000345968 hasConceptScore W2000345968C2780394083 @default.
• W2000345968 hasConceptScore W2000345968C502942594 @default.
• W2000345968 hasConceptScore W2000345968C530470458 @default.
• W2000345968 hasConceptScore W2000345968C71924100 @default.
• W2000345968 hasConceptScore W2000345968C86803240 @default.
• W2000345968 hasIssue "2" @default.
• W2000345968 hasLocation W20003459681 @default.
• W2000345968 hasOpenAccess W2000345968 @default.
• W2000345968 hasPrimaryLocation W20003459681 @default.
• W2000345968 hasRelatedWork W2018368842 @default.
• W2000345968 hasRelatedWork W2034583712 @default.
• W2000345968 hasRelatedWork W2045016490 @default.
• W2000345968 hasRelatedWork W2063619316 @default.
• W2000345968 hasRelatedWork W2074821979 @default.
• W2000345968 hasRelatedWork W2101083005 @default.
• W2000345968 hasRelatedWork W2126532023 @default.
• W2000345968 hasRelatedWork W2169225653 @default.

• next