FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000346711> ?p ?o ?g. }

• W2000346711 endingPage "2224" @default.
• W2000346711 startingPage "2224" @default.
• W2000346711 abstract "To investigate parameters of ocular surface disease in C57BL/6.NOD-Aec1Aec2 (Aec) mice with aging and their correlation with development of Sjögren syndrome (SS)-like lacrimal gland (LG) disease.Aec and C57BL/6 wild-type (B6) female mice were evaluated at 4, 12, and 20 weeks of age. Whole LG and eyes and adnexa were excised for histology and gene expression analysis and evaluated by flow cytometry and immunohistochemistry. Tear volume and goblet cell density was measured. Quantitative PCR evaluated T-cell-related cytokine expression in cornea and conjunctiva.Both strains showed age-related conjunctival goblet cell loss that was more pronounced in the Aec strain and significantly greater than in B6 mice at 12 weeks. This was accompanied by CD4+ T-cell infiltration of the conjunctiva that was greater in Aec strain at 20 weeks. Aec mice had higher levels of IL-17A, IL-17R, IL-1α, IL-1β, and TNF-α in the conjunctiva, and they significantly increase with aging. Aec mice had greater lymphocytic infiltration of the LG and conjunctiva at 20 weeks that consisted of a mixture of CD4+ and CD8+ cells. Flow cytometry showed a significant increase in CD4+ T cells in Aec LG compared to B6 mice. Tear volume was significantly increased in both strains at 20 weeks.Aec mice developed greater conjunctival goblet cell loss associated with lymphocytic infiltration of the LG and conjunctiva with aging. Increased expression of certain T helper or inflammatory cytokines in these tissues was observed in Aec mice. The conjunctival disease appeared to be due to inflammation and not a decrease in tear volume." @default.
• W2000346711 created "2016-06-24" @default.
• W2000346711 creator A5027119261 @default.
• W2000346711 creator A5037905663 @default.
• W2000346711 creator A5053189469 @default.
• W2000346711 creator A5057446569 @default.
• W2000346711 creator A5086607086 @default.
• W2000346711 date "2015-04-10" @default.
• W2000346711 modified "2023-09-25" @default.
• W2000346711 title "Age-Related Conjunctival Disease in the C57BL/6.NOD-<i>Aec1Aec2</i>Mouse Model of Sjögren Syndrome Develops Independent of Lacrimal Dysfunction" @default.
• W2000346711 cites W147432272 @default.
• W2000346711 cites W1497537116 @default.
• W2000346711 cites W1515437374 @default.
• W2000346711 cites W1965841152 @default.
• W2000346711 cites W1969262791 @default.
• W2000346711 cites W1979217548 @default.
• W2000346711 cites W1989691286 @default.
• W2000346711 cites W1992197229 @default.
• W2000346711 cites W1992216350 @default.
• W2000346711 cites W2002180108 @default.
• W2000346711 cites W2009124293 @default.
• W2000346711 cites W2012344956 @default.
• W2000346711 cites W2020341757 @default.
• W2000346711 cites W2022946215 @default.
• W2000346711 cites W2024119736 @default.
• W2000346711 cites W2024155121 @default.
• W2000346711 cites W2024921065 @default.
• W2000346711 cites W2029316558 @default.
• W2000346711 cites W2044287356 @default.
• W2000346711 cites W2045056521 @default.
• W2000346711 cites W2045575169 @default.
• W2000346711 cites W2049207532 @default.
• W2000346711 cites W2051576546 @default.
• W2000346711 cites W2056190025 @default.
• W2000346711 cites W2057962630 @default.
• W2000346711 cites W2073928828 @default.
• W2000346711 cites W2074357311 @default.
• W2000346711 cites W2080497172 @default.
• W2000346711 cites W2088412824 @default.
• W2000346711 cites W2091459368 @default.
• W2000346711 cites W2093642893 @default.
• W2000346711 cites W2100114399 @default.
• W2000346711 cites W2123142399 @default.
• W2000346711 cites W2123870690 @default.
• W2000346711 cites W2127257720 @default.
• W2000346711 cites W2129476710 @default.
• W2000346711 cites W2134037078 @default.
• W2000346711 cites W2137168211 @default.
• W2000346711 cites W2163927668 @default.
• W2000346711 cites W2400543043 @default.
• W2000346711 cites W2401936860 @default.
• W2000346711 cites W27632251 @default.
• W2000346711 cites W2103248174 @default.
• W2000346711 doi "https://doi.org/10.1167/iovs.14-15668" @default.
• W2000346711 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4687887" @default.
• W2000346711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25758816" @default.
• W2000346711 hasPublicationYear "2015" @default.
• W2000346711 type Work @default.
• W2000346711 sameAs 2000346711 @default.
• W2000346711 citedByCount "31" @default.
• W2000346711 countsByYear W20003467112015 @default.
• W2000346711 countsByYear W20003467112016 @default.
• W2000346711 countsByYear W20003467112017 @default.
• W2000346711 countsByYear W20003467112018 @default.
• W2000346711 countsByYear W20003467112019 @default.
• W2000346711 countsByYear W20003467112020 @default.
• W2000346711 countsByYear W20003467112021 @default.
• W2000346711 countsByYear W20003467112022 @default.
• W2000346711 countsByYear W20003467112023 @default.
• W2000346711 crossrefType "journal-article" @default.
• W2000346711 hasAuthorship W2000346711A5027119261 @default.
• W2000346711 hasAuthorship W2000346711A5037905663 @default.
• W2000346711 hasAuthorship W2000346711A5053189469 @default.
• W2000346711 hasAuthorship W2000346711A5057446569 @default.
• W2000346711 hasAuthorship W2000346711A5086607086 @default.
• W2000346711 hasBestOaLocation W20003467111 @default.
• W2000346711 hasConcept C121332964 @default.
• W2000346711 hasConcept C142724271 @default.
• W2000346711 hasConcept C153400128 @default.
• W2000346711 hasConcept C167672396 @default.
• W2000346711 hasConcept C203014093 @default.
• W2000346711 hasConcept C204232928 @default.
• W2000346711 hasConcept C2775941134 @default.
• W2000346711 hasConcept C2775984611 @default.
• W2000346711 hasConcept C2776460901 @default.
• W2000346711 hasConcept C2778690821 @default.
• W2000346711 hasConcept C529295009 @default.
• W2000346711 hasConcept C553184892 @default.
• W2000346711 hasConcept C57742111 @default.
• W2000346711 hasConcept C71924100 @default.
• W2000346711 hasConcept C86803240 @default.
• W2000346711 hasConcept C8891405 @default.
• W2000346711 hasConcept C97355855 @default.
• W2000346711 hasConceptScore W2000346711C121332964 @default.
• W2000346711 hasConceptScore W2000346711C142724271 @default.
• W2000346711 hasConceptScore W2000346711C153400128 @default.
• W2000346711 hasConceptScore W2000346711C167672396 @default.
• W2000346711 hasConceptScore W2000346711C203014093 @default.

• next