Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000346934> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2000346934 endingPage "1790" @default.
- W2000346934 startingPage "1785" @default.
- W2000346934 abstract "Group A streptococcal M proteins contain epitopes that crossreact with sarcolemmal membrane proteins of human myocardium and myosin. In the present study, synthetic peptide copies spanning the entire 197-residue pepsin extracted fragment of type 5 M protein were used to localize the myosin-crossreactive epitopes of the molecule. Peptide 84-116 inhibited by 75% the binding of myosin-crossreactive antibodies evoked by pep M5, as determined by ELISA. Immunoblot inhibition studies confirmed that peptide 84-116 almost totally inhibited the binding of pep M5 antibodies to the heavy chain of human cardiac myosin. None of the remaining synthetic peptides, including peptide 1-35, which contains protective epitopes, inhibited antibodies binding to myosin. Two of three rabbits immunized with peptide 84-116 developed low but significant levels of antibodies crossreactive with myosin. Identification of the primary structures containing tissue-crossreactive as opposed to protective epitopes should not only allow the development of safe and effective M protein vaccines, but may also provide insights into the pathogenesis of rheumatic heart disease." @default.
- W2000346934 created "2016-06-24" @default.
- W2000346934 creator A5019840715 @default.
- W2000346934 creator A5068812282 @default.
- W2000346934 date "1986-11-01" @default.
- W2000346934 modified "2023-10-03" @default.
- W2000346934 title "Sequence of myosin-crossreactive epitopes of streptococcal M protein." @default.
- W2000346934 cites W1485162707 @default.
- W2000346934 cites W1490275327 @default.
- W2000346934 cites W1517273307 @default.
- W2000346934 cites W1550798157 @default.
- W2000346934 cites W1563142381 @default.
- W2000346934 cites W1910955449 @default.
- W2000346934 cites W1934585871 @default.
- W2000346934 cites W1981253302 @default.
- W2000346934 cites W2002558410 @default.
- W2000346934 cites W2042943962 @default.
- W2000346934 cites W2091512744 @default.
- W2000346934 cites W2097713397 @default.
- W2000346934 cites W2098470712 @default.
- W2000346934 cites W2129645761 @default.
- W2000346934 cites W2135104633 @default.
- W2000346934 cites W2156857193 @default.
- W2000346934 cites W2166534473 @default.
- W2000346934 cites W235130671 @default.
- W2000346934 doi "https://doi.org/10.1084/jem.164.5.1785" @default.
- W2000346934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2188470" @default.
- W2000346934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2430047" @default.
- W2000346934 hasPublicationYear "1986" @default.
- W2000346934 type Work @default.
- W2000346934 sameAs 2000346934 @default.
- W2000346934 citedByCount "112" @default.
- W2000346934 countsByYear W20003469342012 @default.
- W2000346934 countsByYear W20003469342013 @default.
- W2000346934 countsByYear W20003469342014 @default.
- W2000346934 countsByYear W20003469342015 @default.
- W2000346934 countsByYear W20003469342016 @default.
- W2000346934 countsByYear W20003469342017 @default.
- W2000346934 countsByYear W20003469342019 @default.
- W2000346934 countsByYear W20003469342021 @default.
- W2000346934 countsByYear W20003469342022 @default.
- W2000346934 countsByYear W20003469342023 @default.
- W2000346934 crossrefType "journal-article" @default.
- W2000346934 hasAuthorship W2000346934A5019840715 @default.
- W2000346934 hasAuthorship W2000346934A5068812282 @default.
- W2000346934 hasBestOaLocation W20003469341 @default.
- W2000346934 hasConcept C104317684 @default.
- W2000346934 hasConcept C147483822 @default.
- W2000346934 hasConcept C153911025 @default.
- W2000346934 hasConcept C159047783 @default.
- W2000346934 hasConcept C159654299 @default.
- W2000346934 hasConcept C167625842 @default.
- W2000346934 hasConcept C185592680 @default.
- W2000346934 hasConcept C195616568 @default.
- W2000346934 hasConcept C203014093 @default.
- W2000346934 hasConcept C2779281246 @default.
- W2000346934 hasConcept C55493867 @default.
- W2000346934 hasConcept C6997183 @default.
- W2000346934 hasConcept C86803240 @default.
- W2000346934 hasConceptScore W2000346934C104317684 @default.
- W2000346934 hasConceptScore W2000346934C147483822 @default.
- W2000346934 hasConceptScore W2000346934C153911025 @default.
- W2000346934 hasConceptScore W2000346934C159047783 @default.
- W2000346934 hasConceptScore W2000346934C159654299 @default.
- W2000346934 hasConceptScore W2000346934C167625842 @default.
- W2000346934 hasConceptScore W2000346934C185592680 @default.
- W2000346934 hasConceptScore W2000346934C195616568 @default.
- W2000346934 hasConceptScore W2000346934C203014093 @default.
- W2000346934 hasConceptScore W2000346934C2779281246 @default.
- W2000346934 hasConceptScore W2000346934C55493867 @default.
- W2000346934 hasConceptScore W2000346934C6997183 @default.
- W2000346934 hasConceptScore W2000346934C86803240 @default.
- W2000346934 hasIssue "5" @default.
- W2000346934 hasLocation W20003469341 @default.
- W2000346934 hasLocation W20003469342 @default.
- W2000346934 hasLocation W20003469343 @default.
- W2000346934 hasLocation W20003469344 @default.
- W2000346934 hasOpenAccess W2000346934 @default.
- W2000346934 hasPrimaryLocation W20003469341 @default.
- W2000346934 hasRelatedWork W1500099390 @default.
- W2000346934 hasRelatedWork W1604248381 @default.
- W2000346934 hasRelatedWork W1872459230 @default.
- W2000346934 hasRelatedWork W1964044168 @default.
- W2000346934 hasRelatedWork W2061470026 @default.
- W2000346934 hasRelatedWork W2126284819 @default.
- W2000346934 hasRelatedWork W2313745184 @default.
- W2000346934 hasRelatedWork W2409423269 @default.
- W2000346934 hasRelatedWork W4244618944 @default.
- W2000346934 hasRelatedWork W4379536951 @default.
- W2000346934 hasVolume "164" @default.
- W2000346934 isParatext "false" @default.
- W2000346934 isRetracted "false" @default.
- W2000346934 magId "2000346934" @default.
- W2000346934 workType "article" @default.