FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000347296> ?p ?o ?g. }

• W2000347296 endingPage "326" @default.
• W2000347296 startingPage "318" @default.
• W2000347296 abstract "Tumour-loaded dendritic cells (DCs) from patients with chronic lymphocytic leukaemia (CLL) matured using an α-type 1-polarized DC cocktail (IL-1β/TNF-α/IFN-α/IFN-γ/poly-I:C;αDC1) were recently shown to induce more functional CD8(+) T cells against autologous tumour cells in vitro than DCs matured with the 'standard' cocktail (IL-1β/TNF-α/IL-6/PGE(2) ;PGE(2) DCs). However, the ability of vaccine DCs to induce a type 1-polarized immune response in vivo probably relies on additional features, including their ability to induce a CXCR3-dependent recruitment of NK cells into vaccine-draining lymph nodes. Moreover, their guiding of rare tumour-specific CD8(+) T cells to sites of DC-CD4(+) T cell interactions by secretion of CCL3 and CCL4 is needed. We therefore analysed the chemokine profile and the lymphocyte-attracting ability in vitro of monocyte-derived PGE(2) DCs and αDC1s from patients with CLL. αDC1s produced much higher levels of CXCR3 ligands (CXCL9/CXCL10/CXCL11) than PGE(2) DCs. Functional studies further demonstrated that αDC1s were superior recruiters of both NK and NKT cells. Moreover, αDC1s produced higher levels of CCL3/CCL4 upon CD40 ligation. These findings suggest that functional αDC1s, derived from patients with CLL, produce a desirable NK-, NKT- and CD8(+) T cell-attracting chemokine profile which may favour a guided and Th1-deviated priming of CD8(+) T cells, supporting the idea that αDC1-based vaccines have a higher immunotherapeutic potential than PGE(2) DCs." @default.
• W2000347296 created "2016-06-24" @default.
• W2000347296 creator A5002897182 @default.
• W2000347296 creator A5030712482 @default.
• W2000347296 creator A5043490594 @default.
• W2000347296 creator A5065293944 @default.
• W2000347296 creator A5068914667 @default.
• W2000347296 creator A5070690183 @default.
• W2000347296 date "2011-08-07" @default.
• W2000347296 modified "2023-10-17" @default.
• W2000347296 title "Tumour‐loaded α‐type 1‐polarized Dendritic Cells from Patients with Chronic Lymphocytic Leukaemia Produce a Superior NK‐, NKT‐ and CD8⁺ T Cell‐attracting Chemokine Profile" @default.
• W2000347296 cites W1491815146 @default.
• W2000347296 cites W1558372199 @default.
• W2000347296 cites W1579010799 @default.
• W2000347296 cites W1628124171 @default.
• W2000347296 cites W1680083592 @default.
• W2000347296 cites W1967964424 @default.
• W2000347296 cites W2004326274 @default.
• W2000347296 cites W2021377837 @default.
• W2000347296 cites W2029440792 @default.
• W2000347296 cites W2030227810 @default.
• W2000347296 cites W2038592860 @default.
• W2000347296 cites W2041925366 @default.
• W2000347296 cites W2042155937 @default.
• W2000347296 cites W2044349268 @default.
• W2000347296 cites W2047793228 @default.
• W2000347296 cites W2059715308 @default.
• W2000347296 cites W2069556438 @default.
• W2000347296 cites W2072696666 @default.
• W2000347296 cites W2072927342 @default.
• W2000347296 cites W2074732684 @default.
• W2000347296 cites W2076976919 @default.
• W2000347296 cites W2078176299 @default.
• W2000347296 cites W2078450673 @default.
• W2000347296 cites W2090831287 @default.
• W2000347296 cites W2097191776 @default.
• W2000347296 cites W2098267542 @default.
• W2000347296 cites W2098901296 @default.
• W2000347296 cites W2104157195 @default.
• W2000347296 cites W2111220263 @default.
• W2000347296 cites W2114071274 @default.
• W2000347296 cites W2115855421 @default.
• W2000347296 cites W2116249739 @default.
• W2000347296 cites W2118923225 @default.
• W2000347296 cites W2124878893 @default.
• W2000347296 cites W2137405984 @default.
• W2000347296 cites W2142099365 @default.
• W2000347296 cites W2142808962 @default.
• W2000347296 cites W2152767191 @default.
• W2000347296 cites W2157783262 @default.
• W2000347296 cites W4313342476 @default.
• W2000347296 doi "https://doi.org/10.1111/j.1365-3083.2011.02580.x" @default.
• W2000347296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21595737" @default.
• W2000347296 hasPublicationYear "2011" @default.
• W2000347296 type Work @default.
• W2000347296 sameAs 2000347296 @default.
• W2000347296 citedByCount "23" @default.
• W2000347296 countsByYear W20003472962012 @default.
• W2000347296 countsByYear W20003472962013 @default.
• W2000347296 countsByYear W20003472962014 @default.
• W2000347296 countsByYear W20003472962015 @default.
• W2000347296 countsByYear W20003472962016 @default.
• W2000347296 countsByYear W20003472962017 @default.
• W2000347296 countsByYear W20003472962018 @default.
• W2000347296 countsByYear W20003472962019 @default.
• W2000347296 countsByYear W20003472962020 @default.
• W2000347296 countsByYear W20003472962022 @default.
• W2000347296 crossrefType "journal-article" @default.
• W2000347296 hasAuthorship W2000347296A5002897182 @default.
• W2000347296 hasAuthorship W2000347296A5030712482 @default.
• W2000347296 hasAuthorship W2000347296A5043490594 @default.
• W2000347296 hasAuthorship W2000347296A5065293944 @default.
• W2000347296 hasAuthorship W2000347296A5068914667 @default.
• W2000347296 hasAuthorship W2000347296A5070690183 @default.
• W2000347296 hasBestOaLocation W20003472961 @default.
• W2000347296 hasConcept C100701293 @default.
• W2000347296 hasConcept C116484652 @default.
• W2000347296 hasConcept C12823836 @default.
• W2000347296 hasConcept C13373296 @default.
• W2000347296 hasConcept C139563560 @default.
• W2000347296 hasConcept C149532602 @default.
• W2000347296 hasConcept C154317977 @default.
• W2000347296 hasConcept C167672396 @default.
• W2000347296 hasConcept C185592680 @default.
• W2000347296 hasConcept C202751555 @default.
• W2000347296 hasConcept C203014093 @default.
• W2000347296 hasConcept C25532541 @default.
• W2000347296 hasConcept C2776090121 @default.
• W2000347296 hasConcept C2778170410 @default.
• W2000347296 hasConcept C502942594 @default.
• W2000347296 hasConcept C55493867 @default.
• W2000347296 hasConcept C5858377 @default.
• W2000347296 hasConcept C59822182 @default.
• W2000347296 hasConcept C79484868 @default.
• W2000347296 hasConcept C81444415 @default.
• W2000347296 hasConcept C86803240 @default.
• W2000347296 hasConcept C8891405 @default.
• W2000347296 hasConceptScore W2000347296C100701293 @default.

• next