Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000349180> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2000349180 endingPage "1532" @default.
- W2000349180 startingPage "1528" @default.
- W2000349180 abstract "Objectives Excessive blood loss in a rat model of uncontrolled hemorrhage has been attributed to the vasodilatory effects of a droperidol-ketamine mixture used for anesthesia. The present study compared responses to droperidol-ketamine and pentobarbital with those responses of a control group without anesthesia during uncontrolled hemorrhage. Design Prospective, randomized, controlled trial. Setting University surgical research laboratory. Subjects Forty-five female Sprague-Dawley rats (210 to 275 g). Interventions Rats were randomly divided into three groups of 15 each according to the type of anesthesia: unanesthetized; pentobarbital; and droperidol-ketamine. A 75% tail resection was used to initiate hemorrhage. Mortality, survival time, and blood loss were monitored, and the differences between all three groups were tested using chi2 test (mortality) and one-way analysis of variance (ANOVA) (survival and blood loss) for statistical significance. Measurements and Results Mean blood loss amounts at 15 mins were 8.9, 13.6, and 22.4 mL/kg for the unanesthetized, pentobarbital, and droperidol-ketamine groups, respectively. Mortality rates for the three groups were 0%, 0%, and 53% at 30 mins and 60%, 33%, and 93% at 90 mins, respectively. Mean survival times for these groups were 94, 135, and 39 mins, respectively. Conclusions An excessive rate of blood loss due to the use of droperidol-ketamine anesthesia renders this model inappropriate for investigation of uncontrolled hemorrhage. The response of rats under pentobarbital anesthesia more closely approximates that of unanesthetized rats. However, the higher mortality rate despite the lesser hemorrhage observed in the latter group seems to indicate the existence of other factors (in addition to blood loss) that may contribute to the early death of these animals. (Crit Care Med 1995; 23:1528-1532)" @default.
- W2000349180 created "2016-06-24" @default.
- W2000349180 creator A5003810991 @default.
- W2000349180 creator A5011434859 @default.
- W2000349180 creator A5013115335 @default.
- W2000349180 creator A5044280254 @default.
- W2000349180 creator A5048851975 @default.
- W2000349180 creator A5070371868 @default.
- W2000349180 date "1995-09-01" @default.
- W2000349180 modified "2023-10-17" @default.
- W2000349180 title "Effects of anesthesia on a model of uncontrolled hemorrhage in rats" @default.
- W2000349180 cites W1964705517 @default.
- W2000349180 cites W1967976796 @default.
- W2000349180 cites W1971777262 @default.
- W2000349180 cites W1994367348 @default.
- W2000349180 cites W2010094703 @default.
- W2000349180 cites W2014400073 @default.
- W2000349180 cites W2070307440 @default.
- W2000349180 cites W2081980824 @default.
- W2000349180 cites W2088117829 @default.
- W2000349180 cites W4248769541 @default.
- W2000349180 doi "https://doi.org/10.1097/00003246-199509000-00013" @default.
- W2000349180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7664555" @default.
- W2000349180 hasPublicationYear "1995" @default.
- W2000349180 type Work @default.
- W2000349180 sameAs 2000349180 @default.
- W2000349180 citedByCount "23" @default.
- W2000349180 countsByYear W20003491802012 @default.
- W2000349180 countsByYear W20003491802014 @default.
- W2000349180 crossrefType "journal-article" @default.
- W2000349180 hasAuthorship W2000349180A5003810991 @default.
- W2000349180 hasAuthorship W2000349180A5011434859 @default.
- W2000349180 hasAuthorship W2000349180A5013115335 @default.
- W2000349180 hasAuthorship W2000349180A5044280254 @default.
- W2000349180 hasAuthorship W2000349180A5048851975 @default.
- W2000349180 hasAuthorship W2000349180A5070371868 @default.
- W2000349180 hasConcept C126322002 @default.
- W2000349180 hasConcept C141071460 @default.
- W2000349180 hasConcept C2776755955 @default.
- W2000349180 hasConcept C2779425338 @default.
- W2000349180 hasConcept C2780795376 @default.
- W2000349180 hasConcept C2781072394 @default.
- W2000349180 hasConcept C2991743468 @default.
- W2000349180 hasConcept C42219234 @default.
- W2000349180 hasConcept C71924100 @default.
- W2000349180 hasConcept C99476002 @default.
- W2000349180 hasConceptScore W2000349180C126322002 @default.
- W2000349180 hasConceptScore W2000349180C141071460 @default.
- W2000349180 hasConceptScore W2000349180C2776755955 @default.
- W2000349180 hasConceptScore W2000349180C2779425338 @default.
- W2000349180 hasConceptScore W2000349180C2780795376 @default.
- W2000349180 hasConceptScore W2000349180C2781072394 @default.
- W2000349180 hasConceptScore W2000349180C2991743468 @default.
- W2000349180 hasConceptScore W2000349180C42219234 @default.
- W2000349180 hasConceptScore W2000349180C71924100 @default.
- W2000349180 hasConceptScore W2000349180C99476002 @default.
- W2000349180 hasIssue "9" @default.
- W2000349180 hasLocation W20003491801 @default.
- W2000349180 hasLocation W20003491802 @default.
- W2000349180 hasOpenAccess W2000349180 @default.
- W2000349180 hasPrimaryLocation W20003491801 @default.
- W2000349180 hasRelatedWork W2049446225 @default.
- W2000349180 hasRelatedWork W2052138923 @default.
- W2000349180 hasRelatedWork W2072650035 @default.
- W2000349180 hasRelatedWork W2081983135 @default.
- W2000349180 hasRelatedWork W2082495868 @default.
- W2000349180 hasRelatedWork W2103127060 @default.
- W2000349180 hasRelatedWork W2389750829 @default.
- W2000349180 hasRelatedWork W2412192184 @default.
- W2000349180 hasRelatedWork W3143983886 @default.
- W2000349180 hasRelatedWork W4232521044 @default.
- W2000349180 hasVolume "23" @default.
- W2000349180 isParatext "false" @default.
- W2000349180 isRetracted "false" @default.
- W2000349180 magId "2000349180" @default.
- W2000349180 workType "article" @default.